| Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion. | |
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MedLine Citation:
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PMID: 22217880 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hypercalciuria is one of the early manifestations of diabetic nephropathy. We explored here the role of α-Klotho, a protein expressed predominantly in distal convoluted tubules that has a role in calcium reabsorption. We studied 31 patients with early diabetic nephropathy and compared them with 31 patients with IgA nephropathy and 7 with minimal change disease. Renal α-Klotho expression was significantly lower and urinary calcium excretion (UCa/UCr) significantly higher in diabetic nephropathy than in IgA nephropathy or minimal change disease. Multiple regression analyses indicated that α-Klotho mRNA was inversely correlated with calcium excretion. We next measured these parameters in a mouse model of streptozotocin (STZ)-induced diabetic nephropathy, characterized by glomerular hyperfiltration, as seen in early diabetic nephropathy. We also confirmed a reduction of renal α-Klotho mRNA down to almost 50% and enhanced calcium excretion in mice with STZ-induced diabetic nephropathy in comparison with nondiabetic mice. Hypercalciuria was exacerbated in heterozygous α-Klotho knockout mice in comparison with wild-type mice, each with STZ-induced diabetic nephropathy. Thus, α-Klotho expression was decreased in distal convoluted tubules in diabetic nephropathy in humans and mice. Renal loss of α-Klotho may affect urinary calcium excretion in early diabetic nephropathy.Kidney International advance online publication, 4 January 2012; doi:10.1038/ki.2011.423. |
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Authors:
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Osamu Asai; Kimihiko Nakatani; Tomohiro Tanaka; Hirokazu Sakan; Akihiro Imura; Shuhei Yoshimoto; Ken-Ichi Samejima; Yukinari Yamaguchi; Masaru Matsui; Yasuhiro Akai; Noboru Konishi; Masayuki Iwano; Yoichi Nabeshima; Yoshihiko Saito |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-04 |
Journal Detail:
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Title: Kidney international Volume: - ISSN: 1523-1755 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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First Department of Internal Medicine, Nara Medical University, Kashihara, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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