| Decreased raphe serotonin in rabbits with experimental herpes simplex encephalitis. | |
| | |
MedLine Citation:
|
PMID: 7692357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Increased monoamine metabolism in experimental herpes simplex virus (HSV) encephalitis is well established. Both serotonin (5-HT) and dopamine (DA) systems are affected. HSV invades the raphe nuclei after its entry into the brain stem. However, no studies have been published concerning influences of HSV on the neurotransmitters in the raphe. In the present study, concentrations of 5-HT and DA and their metabolites in the raphe nuclei and related brain regions in rabbits with fulminant HSV encephalitis have been analyzed using high-pressure liquid chromatography. Encephalitis was induced by corneal inoculation with HSV. Homovanillic acid (HVA) and dihydroxyphenyl acetic acid (DOPAC) concentrations and HVA/DA ratios were increased in the raphe nuclei suggesting increased DA turnover. The most substantial changes were bilaterally decreased 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the raphe nuclei. The decrease in the raphe 5-HT was reflected also to the projection areas in the hemispheres, where 5-HT concentrations were lower in HSV-inoculated rabbits than in controls. The changes strongly suggest a direct influence of HSV on serotoninergic neurons. Since the ventral parts of the limbic system have rich serotoninergic afferents from the raphe, this also suggests that HSV may reach hemispheres in HSV encephalitis from the brain stem via the ascending serotoninergic system. |
| | |
Authors:
|
M A Päivärinta; R J Marttila; P Lönnberg; U K Rinne |
Related Documents
:
|
12684897 - Comparative values of catecholamines and metabolites for the diagnosis of neuroblastoma. 11182237 - Element composition and biochemical components of dirofilaria immitis. 7362857 - Amino acids in the amniotic fluid of diabetic mothers. 890207 - The effects of morphine on the accumulation of homovanillic and 5-hydroxyindoleacetic a... 2865977 - Role of stearoyl-coa desaturase and 1-acylglycerophosphorylcholine acyltransferase in t... 11248677 - Biosynthesis of cannabinoids. incorporation experiments with (13)c-labeled glucoses. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuroscience letters Volume: 156 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1993 Jun |
Date Detail:
|
Created Date: 1993-11-16 Completed Date: 1993-11-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 1-4 Citation Subset: IM |
Affiliation:
|
Department of Neurology, University of Turku, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3,4-Dihydroxyphenylacetic Acid
/
metabolism Animals Brain / metabolism* Caudate Nucleus / metabolism Dopamine / metabolism Encephalitis / metabolism* Female Herpes Simplex / metabolism* Homovanillic Acid / metabolism Hydroxyindoleacetic Acid / metabolism Norepinephrine / metabolism Nucleus Accumbens / metabolism Olfactory Bulb / metabolism Organ Specificity Putamen / metabolism Rabbits Raphe Nuclei / metabolism* Serotonin / metabolism* Simplexvirus* |
| Chemical | |
Reg. No./Substance:
|
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antibodies to hepatitis C virus (HCV) and transaminase concentration in chronic haemodialysis patien...
Next Document: Distribution of NADPH-diaphorase in the cerebral blood vessels of rats: a histochemical study.