Document Detail

Decreased raphe serotonin in rabbits with experimental herpes simplex encephalitis.
MedLine Citation:
PMID:  7692357     Owner:  NLM     Status:  MEDLINE    
Increased monoamine metabolism in experimental herpes simplex virus (HSV) encephalitis is well established. Both serotonin (5-HT) and dopamine (DA) systems are affected. HSV invades the raphe nuclei after its entry into the brain stem. However, no studies have been published concerning influences of HSV on the neurotransmitters in the raphe. In the present study, concentrations of 5-HT and DA and their metabolites in the raphe nuclei and related brain regions in rabbits with fulminant HSV encephalitis have been analyzed using high-pressure liquid chromatography. Encephalitis was induced by corneal inoculation with HSV. Homovanillic acid (HVA) and dihydroxyphenyl acetic acid (DOPAC) concentrations and HVA/DA ratios were increased in the raphe nuclei suggesting increased DA turnover. The most substantial changes were bilaterally decreased 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the raphe nuclei. The decrease in the raphe 5-HT was reflected also to the projection areas in the hemispheres, where 5-HT concentrations were lower in HSV-inoculated rabbits than in controls. The changes strongly suggest a direct influence of HSV on serotoninergic neurons. Since the ventral parts of the limbic system have rich serotoninergic afferents from the raphe, this also suggests that HSV may reach hemispheres in HSV encephalitis from the brain stem via the ascending serotoninergic system.
M A Päivärinta; R J Marttila; P Lönnberg; U K Rinne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  156     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-11-16     Completed Date:  1993-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Department of Neurology, University of Turku, Finland.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Brain / metabolism*
Caudate Nucleus / metabolism
Dopamine / metabolism
Encephalitis / metabolism*
Herpes Simplex / metabolism*
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Norepinephrine / metabolism
Nucleus Accumbens / metabolism
Olfactory Bulb / metabolism
Organ Specificity
Putamen / metabolism
Raphe Nuclei / metabolism*
Serotonin / metabolism*
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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