Document Detail

Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease.
MedLine Citation:
PMID:  12895452     Owner:  NLM     Status:  MEDLINE    
Increasing evidence indicates that mitochondrial dysfunction occurs in the central nervous system as well as in the peripheral tissues from Alzheimer's disease (AD) patients. We have recently shown that mitochondrial cytochrome c oxidase (COX) activity is significantly reduced in brain and platelets from AD patients compared to controls. In the present study we investigated whether impaired COX activity could have functional consequences on energy metabolism. Blood lactate concentration was monitored at rest and during incremental exercise in 22 AD patients in whom COX activity in platelets was decreased compared to controls (35.7 +/- 11.4 vs 48.4 +/- 1.4 nmol/min/mg, P < 0.01). In both resting and exercising conditions, blood lactate was significantly higher in AD patients than in controls. Although the magnitude of exercise-related lactate accumulation was not different between the two groups, an anticipated anaerobic lactate threshold during the incremental forearm exercise was found in AD patients (50% of maximal voluntary contraction MVC compared to 60% in controls). COX activity was inversely related to lactate at a significant level for resting condition (r = -0.65) and borderline for anaerobic threshold exercise level. These results support the hypothesis of a systemic impairment of the mitochondrial function in AD and indicate that decreased COX activity could have functional consequences on metabolism.
Michelangelo Mancuso; Massimiliano Filosto; Francesca Bosetti; Roberto Ceravolo; Anna Rocchi; Gloria Tognoni; Maria Laura Manca; Giancarlo Solaini; Gabriele Siciliano; Luigi Murri
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental neurology     Volume:  182     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-04     Completed Date:  2003-09-16     Revised Date:  2014-03-17    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-6     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / diagnosis,  physiopathology*
Blood Platelets / enzymology*
Electron Transport Complex IV / metabolism*
Energy Metabolism
Exercise Test
Lactic Acid / blood*
Middle Aged
Mitochondria / enzymology
Neuropsychological Tests
Physical Exertion*
Reference Values
Grant Support
Reg. No./Substance:
33X04XA5AT/Lactic Acid; EC Transport Complex IV

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