Document Detail


Decreased plasma pancreatic polypeptide levels in pregnancy.
MedLine Citation:
PMID:  7204535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pancreatic polypeptide (PP) response to oral glucose ingestion was determined in late pregnancy and post partum in 11 normal healthy women. Glucose tolerance was significantly impaired in pregnancy compared to post partum. Fasting plasma PP concentrations were reduced in pregnancy [7.6 +/- 1.2 vs. 12.6 +/- 1.2 pmol liter-1 (mean +/0- SE); P less than 0.01]. The levels of PP increased after glucose ingestion during pregnancy as well as post partum, but the PP response was significantly impaired in gestation (integrated PP responses: 548 +/- 331 vs. 1645 +/- 347 pmol liter-1 min-1; P less than 0.01). It is concluded that in pregnancy, PP levels after an overnight fast are decreased and the PP response to glucose is diminished compared to post partum.
Authors:
P J Hornnes; C Kühl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  52     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  605-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / analysis
Fasting
Female
Glucose / diagnostic use
Humans
Pancreatic Polypeptide / blood*
Pregnancy*
Chemical
Reg. No./Substance:
0/Blood Glucose; 50-99-7/Glucose; 59763-91-6/Pancreatic Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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