Document Detail

Decreased plasma levels of soluble receptor for advanced glycation end-products in patients with essential hypertension.
MedLine Citation:
PMID:  16093918     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Advanced glycation end-products (AGE) may cause vascular stiffening by forming crosslinks through the collagen molecule or by interaction with their cellular transductional receptor (RAGE). A secreted isoform of RAGE, termed soluble RAGE (sRAGE), may contribute to the removal/detoxification of AGE by acting as a decoy. Here we studied the plasma sRAGE levels in hypertensive and normotensive human subjects. We also investigated the relationship between blood pressure parameters and plasma sRAGE concentrations. DESIGN: A cross-sectional case-control study. SETTING AND PARTICIPANTS: The outpatient clinic of a university teaching hospital. Participants were 147 never-treated patients with essential hypertension (87 men and 60 women, aged 50 +/- 10 years) and 177 normotensive controls (118 men and 59 women, aged 49 +/- 10 years). MAIN OUTCOME MEASURES: Plasma sRAGE levels determined by enzyme-linked immunosorbent assay, systolic blood pressure (SBP), diastolic blood pressure, pulse pressure (PP) and mean arterial pressure. RESULTS: The plasma concentration of sRAGE [median (interquartile range)] was 1206 (879-1658) pg/ml in hypertensive subjects and 1359 (999-2198) pg/ml in normotensive controls (P = 0.002). Simple correlation analysis revealed that log-transformed sRAGE levels were inversely correlated with SBP (r = -0.11; P < 0.001) and PP (r = -0.23; P < 0.001). Forward-selection multiple regression analysis revealed that log-transformed sRAGE levels were determined more strongly by PP (F = 3.127, P < 0.001). CONCLUSIONS: Plasma sRAGE levels are decreased in patients with essential hypertension and are inversely related to PP. Our results raise the possibility that sRAGE may play a role in arterial stiffening and its complications.
Diego Geroldi; Colomba Falcone; Enzo Emanuele; Angela D'Angelo; Margherita Calcagnino; Maria P Buzzi; Giuseppe A Scioli; Roberto Fogari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  23     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-11     Completed Date:  2005-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1725-9     Citation Subset:  IM    
Interdepartmental Center for Research in Molecular Medicine (CIRMC), Department of Internal Medicine and Medical Therapeutics, IRCCS San Matteo Hospital, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.
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MeSH Terms
Blood Glucose / analysis
Blood Pressure
Cholesterol / blood
Creatinine / blood
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Hypertension / blood*,  physiopathology
Insulin / blood
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Middle Aged
Potassium / blood
Receptors, Immunologic / blood*,  metabolism
Regression Analysis
Sodium / blood
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Receptors, Immunologic; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol; 60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium

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