| Decreased plasma levels of soluble receptor for advanced glycation end-products in patients with essential hypertension. | |
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MedLine Citation:
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PMID: 16093918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Advanced glycation end-products (AGE) may cause vascular stiffening by forming crosslinks through the collagen molecule or by interaction with their cellular transductional receptor (RAGE). A secreted isoform of RAGE, termed soluble RAGE (sRAGE), may contribute to the removal/detoxification of AGE by acting as a decoy. Here we studied the plasma sRAGE levels in hypertensive and normotensive human subjects. We also investigated the relationship between blood pressure parameters and plasma sRAGE concentrations. DESIGN: A cross-sectional case-control study. SETTING AND PARTICIPANTS: The outpatient clinic of a university teaching hospital. Participants were 147 never-treated patients with essential hypertension (87 men and 60 women, aged 50 +/- 10 years) and 177 normotensive controls (118 men and 59 women, aged 49 +/- 10 years). MAIN OUTCOME MEASURES: Plasma sRAGE levels determined by enzyme-linked immunosorbent assay, systolic blood pressure (SBP), diastolic blood pressure, pulse pressure (PP) and mean arterial pressure. RESULTS: The plasma concentration of sRAGE [median (interquartile range)] was 1206 (879-1658) pg/ml in hypertensive subjects and 1359 (999-2198) pg/ml in normotensive controls (P = 0.002). Simple correlation analysis revealed that log-transformed sRAGE levels were inversely correlated with SBP (r = -0.11; P < 0.001) and PP (r = -0.23; P < 0.001). Forward-selection multiple regression analysis revealed that log-transformed sRAGE levels were determined more strongly by PP (F = 3.127, P < 0.001). CONCLUSIONS: Plasma sRAGE levels are decreased in patients with essential hypertension and are inversely related to PP. Our results raise the possibility that sRAGE may play a role in arterial stiffening and its complications. |
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Authors:
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Diego Geroldi; Colomba Falcone; Enzo Emanuele; Angela D'Angelo; Margherita Calcagnino; Maria P Buzzi; Giuseppe A Scioli; Roberto Fogari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 23 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-11 Completed Date: 2005-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1725-9 Citation Subset: IM |
Affiliation:
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Interdepartmental Center for Research in Molecular Medicine (CIRMC), Department of Internal Medicine and Medical Therapeutics, IRCCS San Matteo Hospital, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy. d.geroldi@smatteo.pv.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / analysis Blood Pressure Cholesterol / blood Creatinine / blood Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Female Humans Hypertension / blood*, physiopathology Insulin / blood Lipoproteins, HDL / blood Lipoproteins, LDL / blood Male Middle Aged Potassium / blood Receptors, Immunologic / blood*, metabolism Regression Analysis Sodium / blood Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Receptors, Immunologic; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol; 60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium |
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