Document Detail


Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1.
MedLine Citation:
PMID:  20167999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.
Authors:
Carmela Pinnetti; Enrica Tamburrini; Enzo Ragazzoni; Andrea De Luca; Pierluigi Navarra
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Antiviral therapy     Volume:  15     ISSN:  2040-2058     ISO Abbreviation:  Antivir. Ther. (Lond.)     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-19     Completed Date:  2010-05-07     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9815705     Medline TA:  Antivir Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  127-9     Citation Subset:  IM    
Affiliation:
Department of Infectious Diseases, Catholic University, Rome, Italy. carmenpinnetti@yahoo.it
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MeSH Terms
Descriptor/Qualifier:
Drug Resistance, Multiple, Viral*
Drug Therapy, Combination
Female
Fetal Blood / chemistry
HIV Infections / blood,  drug therapy*,  transmission
HIV Protease Inhibitors / blood,  pharmacokinetics*,  therapeutic use
HIV-1 / drug effects*,  genetics
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Pregnancy
Pregnancy Complications, Infectious / blood,  drug therapy*,  virology
RNA, Viral / genetics,  isolation & purification
Ritonavir / blood,  pharmacokinetics*,  therapeutic use
Sulfonamides / blood,  pharmacokinetics*,  therapeutic use
Young Adult
Chemical
Reg. No./Substance:
0/HIV Protease Inhibitors; 0/RNA, Viral; 0/Ritonavir; 0/Sulfonamides; YO603Y8113/darunavir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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