Document Detail

Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1.
MedLine Citation:
PMID:  20167999     Owner:  NLM     Status:  MEDLINE    
We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.
Carmela Pinnetti; Enrica Tamburrini; Enzo Ragazzoni; Andrea De Luca; Pierluigi Navarra
Related Documents :
9817869 - Prenatal diagnosis of congenital cytomegalovirus infection.
16260369 - Parvovirus b19 in pregnancy.
21482599 - Systematic review of pregnancy in women with inherited cardiomyopathies.
11399889 - Sepsis in second trimester of pregnancy due to an infected myoma. a case report and a r...
22534079 - Clustering of maternal/fetal clinical conditions and outcomes and placental lesions.
20167999 - Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman ...
1531949 - Fetal growth in aneuploid conditions.
22644829 - The effect of maternal obesity on pregnancy outcomes of women with gestational diabetes...
12535289 - Reproducibility of repeated measurements on post-burn scars with dermascan c.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Antiviral therapy     Volume:  15     ISSN:  2040-2058     ISO Abbreviation:  Antivir. Ther. (Lond.)     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-19     Completed Date:  2010-05-07     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9815705     Medline TA:  Antivir Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  127-9     Citation Subset:  IM    
Department of Infectious Diseases, Catholic University, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Drug Resistance, Multiple, Viral*
Drug Therapy, Combination
Fetal Blood / chemistry
HIV Infections / blood,  drug therapy*,  transmission
HIV Protease Inhibitors / blood,  pharmacokinetics*,  therapeutic use
HIV-1 / drug effects*,  genetics
Infant, Newborn
Infectious Disease Transmission, Vertical
Pregnancy Complications, Infectious / blood,  drug therapy*,  virology
RNA, Viral / genetics,  isolation & purification
Ritonavir / blood,  pharmacokinetics*,  therapeutic use
Sulfonamides / blood,  pharmacokinetics*,  therapeutic use
Young Adult
Reg. No./Substance:
0/HIV Protease Inhibitors; 0/RNA, Viral; 0/Ritonavir; 0/Sulfonamides; YO603Y8113/darunavir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  HIV contamination of commercial PCR enzymes raises the importance of quality control of low-cost in-...
Next Document:  Classification of prefrontal activity due to mental arithmetic and music imagery using hidden Markov...