| Decreased plasma level of vitamin C in chronic kidney disease: comparison between diabetic and non-diabetic patients. | |
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MedLine Citation:
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PMID: 20817670 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: A decreased plasma level of vitamin C has been reported to be associated with an increased risk of cardiovascular morbidity and mortality. Here, we sought to determine the vitamin C status of patients with chronic kidney disease and the pathophysiological role of vitamin C in these patients. METHODS: We studied 58 patients and evaluated the relationship between renal function and plasma vitamin C concentration, as well as the effect of diabetes on this relationship. Endothelium-dependent flow-mediated dilation of brachial artery was measured to assess the endothelial function. Serum malondialdehyde low-density lipoprotein was measured as a marker for oxidative stress. RESULTS: Plasma vitamin C concentration had a positive linear relationship with eGFR in both diabetic and non-diabetic patients (P = 0.006 and P = 0.004, respectively). When vitamin C concentration and eGFR relationships were compared in the two groups, vitamin C concentration was significantly lower in diabetic patients at every eGFR (P = 0.006). Flow-mediated vasodilatation of the brachial artery was positively correlated with vitamin C concentration in non-diabetic patients (P = 0.047) but not in diabetic patients. There was a negative correlation between serum malondialdehyde low-density lipoprotein and vitamin C concentration in non-diabetic patients (P = 0.044) but not in diabetic patients. CONCLUSIONS: Renal dysfunction was associated with a decrease in plasma vitamin C level. Moreover, decreased vitamin C may cause endothelial dysfunction via an increase in oxidative stress in non-diabetic chronic kidney disease patients. |
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Authors:
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Nobuyuki Takahashi; Satoshi Morimoto; Mitsuhiko Okigaki; Maiko Seo; Kazunori Someya; Tatsuyori Morita; Hiroaki Matsubara; Tetsuro Sugiura; Toshiji Iwasaka |
Publication Detail:
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Type: Journal Article Date: 2010-09-03 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 26 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 1252-7 Citation Subset: IM |
Affiliation:
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Correspondence and offprint requests to: Nobuyuki Takahashi; E-mail: takahasn@hirakata.kmu.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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