Document Detail

Decreased plakophilin-1 expression promotes increased motility in head and neck squamous cell carcinoma cells.
MedLine Citation:
PMID:  17668353     Owner:  NLM     Status:  MEDLINE    
Desmosomes are prominent cell-cell adhesive junctions found in a variety of epithelial tissues, including the oral epithelium. The transmembrane core of the desmosome is composed of the desmosomal cadherins that interact extracellularly to mediate cell-cell adhesion. The cytoplasmic domain of desmosomal cadherins interact with plaque proteins that in turn interact with the keratin intermediate filament cytoskeleton. Plakophilin 1 is a major desmosomal plaque component that functions to recruit intermediate filaments to sites of cell-cell contact via interactions with desmoplakin. Decreased assembly of desmosomes has been reported in several epithelial cancers. We examined plakophilin-1 expression in an esophageal squamous cell carcinoma tissue microarray and found that plakophilin-1 expression inversely correlates with tumor grade. In addition, we sought to investigate the effect of plakophilin-1 expression on desmosome assembly and cell motility in oral squamous cell carcinoma cell lines. Cell lines expressing altered levels of plakophilin-1 were generated and the ability of these cells to recruit desmoplakin to sites of cell-cell contact was examined. Our results show that decreased expression of plakophilin-1 results in decreased desmosome assembly and increased cell motility and invasion. These data lead us to propose that loss of plakophilin-1 expression during head and neck squamous cell carcinoma (HNSCC) progression may contribute to an invasive phenotype.
Tammy Sobolik-Delmaire; Dawn Katafiasz; Sarah A Keim; My G Mahoney; James K Wahl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell communication & adhesion     Volume:  14     ISSN:  1541-9061     ISO Abbreviation:  Cell Commun. Adhes.     Publication Date:    2007 Mar-Jun
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101096596     Medline TA:  Cell Commun Adhes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-109     Citation Subset:  IM    
Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska, USA.
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MeSH Terms
Carcinoma, Squamous Cell / metabolism*,  pathology*
Cell Line, Tumor
Cell Movement*
Esophageal Neoplasms / metabolism,  pathology
Head and Neck Neoplasms / metabolism*,  pathology*
Mouth Neoplasms / metabolism,  pathology
Neoplasm Invasiveness
Plakophilins / immunology,  metabolism*
Protein Transport
Reg. No./Substance:

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