| Decreased placental oxygenation capacity in pre-eclampsia: clinical application of a novel index of placental function preformed at the time of delivery. | |
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MedLine Citation:
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PMID: 19673683 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We have previously described placental oxygenation capacity as an index of placental function. The aim of this study was to utilize this test to evaluate placental gas exchange capacity in pre-eclampsia and fetal growth restriction (FGR). STUDY DESIGN: Two nested case-control studies were conducted between: (i) pre-eclamptic appropriate-for-gestational-age fetus (AGA) and non-pre-eclamptic AGA; and (ii) pre-eclamptic FGR and non-pre-eclamptic FGR based on gestational age match. Umbilical A-V gas differences were compared between groups. RESULTS: Pre-eclamptic AGA was associated with smaller A-V pO(2) and A-V pCO(2) differences compared to non-pre-eclampsia (A-V pO(2), 7.1+/-3.8 mm Hg vs. 11.3+/-5.9 mm Hg, P=0.001; A-V pCO(2), 7.8+/-5.7 mm Hg vs. 10.7+/- 5.9 mm Hg, P=0.01). Pre-eclamptic FGR was associated with smaller A-V pO(2) and A-V pCO(2) differences compared to non-pre-eclampsia (A-V pO(2), 6.6+/-3.1 mm Hg vs. 10.8+/-8.1 mm Hg, P<0.001; 6.7+/-4.5 mm Hg vs. 10.9+/-10.3 mm Hg, P=0.044). Pre-eclamptic FGR also had significantly lower venous pO(2) but not arterial pO(2) (Venous pO(2), 20.3+/-6.3 mm Hg vs. 25.4+/-11.9 mm Hg, P=0.003). CONCLUSION: Pre-eclampsia decreases the placental oxygenation capacity as measured by the umbilical arterial-venous oxygen difference. |
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Authors:
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Koji Matsuo; Andrew M Malinow; Chris R Harman; Ahmet A Baschat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 37 ISSN: 1619-3997 ISO Abbreviation: J Perinat Med Publication Date: 2009 |
Date Detail:
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Created Date: 2009-11-13 Completed Date: 2010-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 657-61 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Science, University of Maryland School of Medicine, Baltimore, MD 21201, USA. kmats001@umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Delivery, Obstetric Female Fetal Blood / metabolism Fetal Growth Retardation / blood, etiology Humans Infant, Newborn Infant, Small for Gestational Age Maternal-Fetal Exchange / physiology Oxygen / blood, physiology* Parturition / blood, physiology* Placenta / blood supply, physiopathology* Pre-Eclampsia / blood, physiopathology* Pregnancy |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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