Document Detail


Decreased ovarian reserve relates to pre-eclampsia in IVF/ICSI pregnancies.
MedLine Citation:
PMID:  16951429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pre-eclampsia affects 2-10% of all pregnancies and is a major cause of maternal and fetal morbidity and mortality. As compared with the general population, IVF pregnancies are associated with a 2.7-fold risk of pre-eclampsia. An advanced age and associated subfertility in the IVF group reflects a general decrease in ovarian reserve, which itself has been linked to cardiovascular disease. We tested the hypothesis that decreased ovarian reserve is associated with pre-eclampsia as a vascular complication in IVF/ICSI pregnancies. METHODS: In this retrospective case-control study, 41 cases with a history of pre-eclampsia were compared to 82 matched controls without hypertension or (pre)eclampsia. All pregnancies were established after IVF or ICSI. Several indicators of ovarian reserve such as variables related to basal ovarian function and response to hyperstimulation were compared in both the groups by multivariate analysis. The condition of the neonates was evaluated as well. RESULTS: A higher amount of total administered FSH and FSH per day, together with a lower number of obtained oocytes during IVF treatment, were associated with an increased risk to pre-eclampsia in a subsequent pregnancy. The administered FSH per follicle and per obtained oocyte showed even stronger relationships, the latter having the best predictive value. Neonatal outcome was comparable between the groups. CONCLUSION: Diminished responsiveness of the ovaries to FSH stimulation in an IVF cycle, reflecting decreased ovarian reserve, is associated with an increased risk of developing pre-eclampsia in a subsequent pregnancy.
Authors:
G H Woldringh; M H A Frunt; J A M Kremer; M E A Spaanderman
Related Documents :
12571439 - Serum adenosine deaminase activity in women with pre-eclampsia.
7924009 - Volume homeostasis in normal pregnancy and pre-eclampsia: physiology and clinical impli...
16196389 - Oxidative and nitrative injury in periventricular leukomalacia: a review.
6205679 - Beta-human chorionic gonadotrophin levels before and after the development of pre-eclam...
8503209 - Is adolescent pregnancy hazardous?
16105099 - Serum levels of macrophage colony stimulating, vascular endothelial, and placenta growt...
12768409 - Impact of public health strategies on the birth prevalence of cystic fibrosis in britta...
20926839 - Asymmetric syncytial expression of glut9 splice variants in human term placenta and alt...
20936639 - Confined placental mosaicism and pregnancy outcome: a distinction needs to be made betw...
Publication Detail:
Type:  Journal Article     Date:  2006-09-02
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  21     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-12     Completed Date:  2007-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2948-54     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. g.woldringh@obgyn.umcn.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Female
Fertilization in Vitro*
Follicle Stimulating Hormone / blood
Humans
Maternal Age
Ovary / physiopathology*
Pre-Eclampsia / epidemiology*
Pregnancy
Reference Values
Retrospective Studies
Risk Factors
Sperm Injections, Intracytoplasmic*
Chemical
Reg. No./Substance:
9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An ethical analysis of alternative methods to obtain pluripotent stem cells without destroying embry...
Next Document:  Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.