| Decreased nuclear encoded subunits of cytochrome c oxidase and increased copper, zinc-superoxide dismutase activity are found in cardiomyopathic human hearts. | |
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MedLine Citation:
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PMID: 9476686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mineral concentrations, copper, zinc-superoxide dismutase and cytochrome c oxidase subunits in human cardiomyopathic heart explants were compared with noncardiomyopathic hearts from autopsy subjects. Iron was reduced in cardiomyopathic hearts, but the zinc:iron ratio was higher in cardiomyopathic hearts. Copper, zinc-superoxide dismutase activity was increased in cardiomyopathic human hearts compared to the noncardiomyopathic hearts. In a subsample of specimens analyzed, the nuclear encoded subunits of cytochrome c oxidase were diminished in the cardiomyopathic hearts. The decreases have been observed in rodents fed copper-deficient diets. However, in this study heart copper levels did not differ by disease status. |
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Authors:
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R Liebes; D M Medeiros |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 62 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-04-01 Completed Date: 1998-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 259-67 Citation Subset: IM |
Affiliation:
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Department of Human Nutrition and Food Management, The Ohio State University, Columbus 43210-1295, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Calcium / analysis Copper / analysis Electron Transport Complex IV / analysis* Female Gene Expression Regulation, Enzymologic Heart Diseases / enzymology* Humans Iron / analysis Magnesium / analysis Male Middle Aged Myocardium / chemistry* Potassium / analysis Reference Values Sodium / analysis Superoxide Dismutase / analysis* Zinc / analysis |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-50-8/Copper; 7440-66-6/Zinc; 7440-70-2/Calcium; EC 1.15.1.1/Superoxide Dismutase; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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