Document Detail


Decreased nuclear encoded subunits of cytochrome c oxidase and increased copper, zinc-superoxide dismutase activity are found in cardiomyopathic human hearts.
MedLine Citation:
PMID:  9476686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mineral concentrations, copper, zinc-superoxide dismutase and cytochrome c oxidase subunits in human cardiomyopathic heart explants were compared with noncardiomyopathic hearts from autopsy subjects. Iron was reduced in cardiomyopathic hearts, but the zinc:iron ratio was higher in cardiomyopathic hearts. Copper, zinc-superoxide dismutase activity was increased in cardiomyopathic human hearts compared to the noncardiomyopathic hearts. In a subsample of specimens analyzed, the nuclear encoded subunits of cytochrome c oxidase were diminished in the cardiomyopathic hearts. The decreases have been observed in rodents fed copper-deficient diets. However, in this study heart copper levels did not differ by disease status.
Authors:
R Liebes; D M Medeiros
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  62     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-04-01     Completed Date:  1998-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  259-67     Citation Subset:  IM    
Affiliation:
Department of Human Nutrition and Food Management, The Ohio State University, Columbus 43210-1295, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Calcium / analysis
Copper / analysis
Electron Transport Complex IV / analysis*
Female
Gene Expression Regulation, Enzymologic
Heart Diseases / enzymology*
Humans
Iron / analysis
Magnesium / analysis
Male
Middle Aged
Myocardium / chemistry*
Potassium / analysis
Reference Values
Sodium / analysis
Superoxide Dismutase / analysis*
Zinc / analysis
Chemical
Reg. No./Substance:
7439-89-6/Iron; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-50-8/Copper; 7440-66-6/Zinc; 7440-70-2/Calcium; EC 1.15.1.1/Superoxide Dismutase; EC 1.9.3.1/Electron Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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