Document Detail

Decreased nitric oxide production in the rat brain after chronic arsenic exposure.
MedLine Citation:
PMID:  16871439     Owner:  NLM     Status:  MEDLINE    
Chronic arsenic exposure is associated with nervous system damage, vascular disease, hepatic and renal damage as well as different types of cancer. Alterations of nitric oxide (NO) in the periphery have been detected after arsenic exposure, and we explored here NO production in the brain. Female Wistar rats were exposed to arsenite in drinking water (4-5 mg/kg/day) from gestation, lactation and until 4 months of age. NOS activity, NO metabolites content, reactive oxygen species production (ROS) and lipid peroxidation (LPx) were determined in vitro in the striatum, and NO production was estimated in vivo measuring citrulline by microdialysis. Exposed animals showed a significantly lower response to NMDA receptor stimulation, reduction of NOS activity and decreased levels of nitrites and nitrates in striatum. These markers of NO function were accompanied by significantly higher levels of LPx and ROS production. These results provide evidence of NO dysfunction in the rat brain associated with arsenic exposure.
Sergio Zarazúa; Francisca Pérez-Severiano; Juan Manuel Delgado; Luz M Martínez; Deogracias Ortiz-Pérez; María E Jiménez-Capdeville
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-27
Journal Detail:
Title:  Neurochemical research     Volume:  31     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-25     Completed Date:  2007-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1069-77     Citation Subset:  IM    
Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, Av. V. Carranza 2405 Col. Los Filtros, 78210 San Luis Potosí S.L.P., Mexico.
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MeSH Terms
Arsenic / toxicity*
Arsenic Poisoning
Arsenites / administration & dosage,  pharmacology
Body Weight
Brain* / drug effects,  metabolism
Enzyme Inhibitors / administration & dosage,  pharmacology
Nitric Oxide / metabolism*
Nitric Oxide Synthase / antagonists & inhibitors,  metabolism
Oxidative Stress
Rats, Wistar
Sodium Compounds / administration & dosage,  pharmacology
Reg. No./Substance:
0/Arsenites; 0/Enzyme Inhibitors; 0/Sodium Compounds; 10102-43-9/Nitric Oxide; 13768-07-5/sodium arsenite; 7440-38-2/Arsenic; EC Oxide Synthase

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