Document Detail


Decreased nitric oxide production in the rat brain after chronic arsenic exposure.
MedLine Citation:
PMID:  16871439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic arsenic exposure is associated with nervous system damage, vascular disease, hepatic and renal damage as well as different types of cancer. Alterations of nitric oxide (NO) in the periphery have been detected after arsenic exposure, and we explored here NO production in the brain. Female Wistar rats were exposed to arsenite in drinking water (4-5 mg/kg/day) from gestation, lactation and until 4 months of age. NOS activity, NO metabolites content, reactive oxygen species production (ROS) and lipid peroxidation (LPx) were determined in vitro in the striatum, and NO production was estimated in vivo measuring citrulline by microdialysis. Exposed animals showed a significantly lower response to NMDA receptor stimulation, reduction of NOS activity and decreased levels of nitrites and nitrates in striatum. These markers of NO function were accompanied by significantly higher levels of LPx and ROS production. These results provide evidence of NO dysfunction in the rat brain associated with arsenic exposure.
Authors:
Sergio Zarazúa; Francisca Pérez-Severiano; Juan Manuel Delgado; Luz M Martínez; Deogracias Ortiz-Pérez; María E Jiménez-Capdeville
Related Documents :
10094579 - Obesity is associated with increased myocardial oxidative stress.
15661569 - Effect of scutellarin on nitric oxide production in early stages of neuron damage induc...
20623509 - Alleviation of doxorubicin-induced toxicities by anthocyanin-rich bilberry (vaccinium m...
18980479 - Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of...
24633549 - Nox2 and p47phox modulate compensatory growth of primary collateral arteries.
16389659 - Protective role of panax ginseng extract standardized with ginsenoside rg3 against acry...
21937979 - Angiotensin ii-dependent persistent podocyte loss from destabilized glomeruli causes pr...
1904849 - Comparison of compensatory pituitary and testicular responses to hemicastration between...
19260939 - Bumetanide inhibits rapid kindling in neonatal rats.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-27
Journal Detail:
Title:  Neurochemical research     Volume:  31     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-25     Completed Date:  2007-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1069-77     Citation Subset:  IM    
Affiliation:
Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, Av. V. Carranza 2405 Col. Los Filtros, 78210 San Luis Potosí S.L.P., Mexico.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arsenic / toxicity*
Arsenic Poisoning
Arsenites / administration & dosage,  pharmacology
Body Weight
Brain* / drug effects,  metabolism
Enzyme Inhibitors / administration & dosage,  pharmacology
Female
Humans
Male
Nitric Oxide / metabolism*
Nitric Oxide Synthase / antagonists & inhibitors,  metabolism
Oxidative Stress
Pregnancy
Rats
Rats, Wistar
Sodium Compounds / administration & dosage,  pharmacology
Chemical
Reg. No./Substance:
0/Arsenites; 0/Enzyme Inhibitors; 0/Sodium Compounds; 10102-43-9/Nitric Oxide; 13768-07-5/sodium arsenite; 7440-38-2/Arsenic; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms.
Next Document:  Differences in susceptibility of MBP charge isomers to digestion by stromelysin-1 (MMP-3) and releas...