| Decreased nitric oxide production in the rat brain after chronic arsenic exposure. | |
MedLine Citation:
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PMID: 16871439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic arsenic exposure is associated with nervous system damage, vascular disease, hepatic and renal damage as well as different types of cancer. Alterations of nitric oxide (NO) in the periphery have been detected after arsenic exposure, and we explored here NO production in the brain. Female Wistar rats were exposed to arsenite in drinking water (4-5 mg/kg/day) from gestation, lactation and until 4 months of age. NOS activity, NO metabolites content, reactive oxygen species production (ROS) and lipid peroxidation (LPx) were determined in vitro in the striatum, and NO production was estimated in vivo measuring citrulline by microdialysis. Exposed animals showed a significantly lower response to NMDA receptor stimulation, reduction of NOS activity and decreased levels of nitrites and nitrates in striatum. These markers of NO function were accompanied by significantly higher levels of LPx and ROS production. These results provide evidence of NO dysfunction in the rat brain associated with arsenic exposure. |
Authors:
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Sergio Zarazúa; Francisca Pérez-Severiano; Juan Manuel Delgado; Luz M Martínez; Deogracias Ortiz-Pérez; María E Jiménez-Capdeville |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-07-27 |
Journal Detail:
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Title: Neurochemical research Volume: 31 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-25 Completed Date: 2007-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 1069-77 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, Av. V. Carranza 2405 Col. Los Filtros, 78210 San Luis Potosí S.L.P., Mexico. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arsenic / toxicity* Arsenic Poisoning Arsenites / administration & dosage, pharmacology Body Weight Brain* / drug effects, metabolism Enzyme Inhibitors / administration & dosage, pharmacology Female Humans Male Nitric Oxide / metabolism* Nitric Oxide Synthase / antagonists & inhibitors, metabolism Oxidative Stress Pregnancy Rats Rats, Wistar Sodium Compounds / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Arsenites; 0/Enzyme Inhibitors; 0/Sodium Compounds; 10102-43-9/Nitric Oxide; 13768-07-5/sodium arsenite; 7440-38-2/Arsenic; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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