Document Detail

Decreased myocardial Na+K+ATPase activity in rats with reduced renal mass-saline hypertension.
MedLine Citation:
PMID:  3003189     Owner:  NLM     Status:  MEDLINE    
Inhibition of cardiovascular Na,K-pump activity has been shown to promote an increase in the contractile activity of myocardial and vascular smooth muscle and a consequent rise in blood pressure (BP). It has also been shown that vascular Na,K-pump activity and myocardial Na+K+ATPase activity [the energy source for active sodium (Na) and potassium (K) transport] are decreased in rats with various forms of low renin hypertension including rats with reduced renal mass-saline (RRM-saline) hypertension. In the present study, left ventricular Na+K+ATPase activity from rats with RRM-saline hypertension was found to be decreased in membranes prepared by two independent methods: deoxycholate, sodium iodide (Nal)-treated microsomal fractions (method 1) and membranes prepared by the hypotonic, lithium bromide (LiBr) method (method 2). Relative to RRM normotensive control rats which drank distilled water, myocardial Na+K+ATPase activity from RRM-saline drinking rats was decreased by 18.2% in membranes prepared by method 1 and 33.6% in membranes prepared by method 2. The apparent affinities of Na+K+ATPase for K and for ouabain were unaltered relative to controls in membranes prepared from these hypertensive rats by method 1, and the sialic acid content and 5'-nucleotidase activity (two putative sarcolemmal markers) were unaltered in membranes from the hypertensive rats, prepared by methods 1 and 2 respectively. The Mg2+ATPase activity of membranes prepared by method 1 was increased in the RRM-saline hypertensive rats but because it was not increased in membranes prepared by method 2 the former observation does not appear to be of any pathophysiological importance. In other experiments, hypertension was reversed in RRM-saline hypertensive rats by restricting their salt intake (substitution of distilled water for drinking).(ABSTRACT TRUNCATED AT 250 WORDS)
D L Clough; S J Huot; M B Pamnani; F J Haddy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension     Volume:  3     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-03-26     Completed Date:  1986-03-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  583-9     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Body Weight
Cell Membrane / enzymology
Hypertension, Renal / enzymology*,  physiopathology
Myocardium / enzymology*
Ouabain / pharmacology
Rats, Inbred Strains
Sodium Chloride
Sodium-Potassium-Exchanging ATPase / metabolism*
Grant Support
Reg. No./Substance:
630-60-4/Ouabain; 7647-14-5/Sodium Chloride; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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