Document Detail

Decreased muscle ACE activity enhances functional response to endurance training in rats, without change in muscle oxidative capacity or contractile phenotype.
MedLine Citation:
PMID:  19407247     Owner:  NLM     Status:  MEDLINE    
In the present study, we tested the hypothesis that chronic ANG I-converting enzyme (ACE) inhibition could improve the training-induced improvement in endurance exercise performance and that this could be related to enhanced skeletal muscle metabolic efficiency. Female Wistar rats were assigned to four groups comprising animals either maintained sedentary or endurance trained (Sed and Tr, respectively), and treated or not for 10 wk with an ACE inhibitor, perindopril (2 (Per and Ct, respectively) (n = 8 each). Trained rats underwent an 8-wk treadmill training protocol that consisted of 2 h/day running at 30 m/min on a 8% decline. Before the start of and 1 wk before the end of experimental conditioning, the running time to exhaustion of rats was measured on a treadmill. The training program led to an increase in endurance time, higher in Tr-Per than in Tr-Ct group (125% in Tr-Ct vs. 183% in Tr-Per groups, P < 0.05). Oxidative capacity, measured in saponin-permeabilized fibers of slow soleus and fast plantaris muscles, increased with training, but less in Tr-Per than in Tr-Ct rats. The training-induced increase in citrate synthase activity also was less in soleus from Tr-Per than Tr-Ct rats. The training-induced increase in the percentage of the type IIa isoform of myosin heavy chain (MHC) (45%, P < 0.05) and type IIx MHC (25%, P < 0.05) associated with decreased type IIb MHC (34%, P < 0.05) was minimized by perindopril administration. These findings demonstrate that the enhancement in physical performance observed in perindopril-treated animals cannot be explained by changes in mitochondrial respiration and/or MHC distribution within muscles involved in running exercise.
Estelle Habouzit; Hélène Richard; Hervé Sanchez; Nathalie Koulmann; Bernard Serrurier; Rachel Monnet; Renée Ventura-Clapier; Xavier Bigard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-30
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  107     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-01     Completed Date:  2009-08-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  346-53     Citation Subset:  IM    
Département des facteurs humains, Centre de Recherches du Service de Santé des Armées, F-38700 La Tronche, France.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Citrate (si)-Synthase / metabolism
Mitochondria, Muscle / drug effects,  enzymology
Motor Activity / drug effects,  physiology
Muscle Contraction / drug effects,  physiology
Muscle Fibers, Fast-Twitch / drug effects,  metabolism
Muscle Fibers, Skeletal / cytology*,  drug effects,  enzymology*
Muscle Fibers, Slow-Twitch / drug effects,  metabolism
Myosin Heavy Chains / drug effects,  metabolism
Oxygen Consumption / drug effects,  physiology*
Peptidyl-Dipeptidase A / metabolism*
Perindopril / pharmacology
Physical Conditioning, Animal / physiology*
Physical Exertion / drug effects,  physiology
Rats, Wistar
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Myosin Heavy Chains; 82834-16-0/Perindopril; EC (si)-Synthase; EC A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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