Document Detail

Decreased motor unit number estimates in juvenile myoclonic epilepsy.
MedLine Citation:
PMID:  11997730     Owner:  NLM     Status:  MEDLINE    
In this study, motor unit number estimate (MUNE) analysis with McComa's technique was used to detect any change in lower motor neuron count in juvenile myoclonic epilepsy (JME). The study included 10 JME patients, 8 idiopathic generalized epilepsy (IGE) patients, 7 patients with mesial temporal sclerosis (MTS), and 15 normal subjects. All the patients and normal subjects were subjected to MUNE analysis on the abductor pollicis brevis and tibialis anterior muscles, as well as needle electromyography and nerve conduction studies. Electromyographic and nerve conduction studies were normal in all groups. MUNEs in the JME group and were significantly lower than those of normal subjects (P < 0.001). MUNEs of IGE and MTS patients also tended to be lower than that of normal subjects with no significant difference from normal subjects. MUNEs of abductor pollicis brevis and tibialis anterior muscles were 114 +/- 24 and 90 +/- 15 for normal subjects, 59 +/- 18 and 50 +/- 23 for JME patients, 91 +/- 22 and 75 +/- 19 for IGE patients, and 84 +/- 42 and 80 +/- 29 for MTS patients respectively. It may be reasonable to suggest that a genetic origin is responsible for a tendency to contract epilepsy, and the disorganization of lower motor neurons may be shared in JME.
Serhan Sevim; Nalan Kayrak Ertaş; Mustafa Ertaş
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society     Volume:  19     ISSN:  0736-0258     ISO Abbreviation:  J Clin Neurophysiol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-08     Completed Date:  2002-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8506708     Medline TA:  J Clin Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-81     Citation Subset:  IM    
Department of Neurology, Mersin University Faculty of Medicine, Istanbul Faculty of Medicine, Capa, Turkey.
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MeSH Terms
Cell Count / statistics & numerical data
Electromyography / statistics & numerical data
Middle Aged
Motor Neurons / pathology
Muscle, Skeletal / physiopathology*
Myoclonic Epilepsy, Juvenile / physiopathology*
Neural Conduction / physiology

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