Document Detail

Decreased mortality in acute pancreatitis related to early aggressive hydration.
MedLine Citation:
PMID:  21499208     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : Early aggressive intravenous hydration is believed to prevent morbidity and mortality by preventing intravascular volume depletion and maintaining perfusion of the pancreas possibly preventing pancreatic necrosis. The following study was initiated to determine the relationship between the observed decrease in mortality and the role of early aggressive hydration.
METHODS: : A consecutive series of patients with acute pancreatitis from a single community hospital in1998 were compared to a consecutive series of patients with acute pancreatitis from the same institution in 2008.
RESULTS: : Significantly more patients developed pancreatic necrosis; 26 (15%) of 173 patients in 1998 compared to 4 (4%) of 113 patients in 2008. The mean rate of hydration was significantly higher in 2008 compared with that in 1998 (P = 0.02). In 1998, hydration was provided at 184 mL/h during the first 6 hours and 188 mL/h during the first 12 hours compared with 284 mL/h during the first 6 hours and 221 mL/h during the first 12 hours in 2008. There was a significant decrease in mortality in 2008 compared with that in 1998 (3.5% vs 12%, P = 0.03).
CONCLUSIONS: : The decrease in mortality seen in patients with acute pancreatitis during the last decade may be related to the increased aggressive hydration preventing pancreatic necrosis.
Ian Wall; Nison Badalov; Robin Baradarian; Kadirawel Iswara; Jian Jun Li; Scott Tenner
Related Documents :
3249138 - Amyloidosis as a cause of carpal tunnel syndrome in haemodialysis patients.
12137438 - Acute effect of haemodialysis on serum markers of myocardial damage.
4357138 - Changes in skeletal mineral in patients on prolonged maintenance dialysis.
2316588 - Acute renal failure in hypertensive disorders of pregnancy. pregnancy outcome and remot...
7658108 - Red cell aggregability increases with the severity of venous insufficiency.
25221528 - Differential cardiac effects of aerobic interval training versus moderate continuous tr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  40     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  547-50     Citation Subset:  IM    
From the Division of Gastroenterology, Department of Medicine, Maimonides Medical Center, State University of New York - Health Sciences Center, Brooklyn, NY.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intragenic duplication: a novel mutational mechanism in hereditary pancreatitis.
Next Document:  Brain-derived neurotrophic factor is upregulated in rats with chronic pancreatitis and mediates pain...