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Decreased mortality in acute pancreatitis related to early aggressive hydration.
MedLine Citation:
PMID:  21499208     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: : Early aggressive intravenous hydration is believed to prevent morbidity and mortality by preventing intravascular volume depletion and maintaining perfusion of the pancreas possibly preventing pancreatic necrosis. The following study was initiated to determine the relationship between the observed decrease in mortality and the role of early aggressive hydration.
METHODS: : A consecutive series of patients with acute pancreatitis from a single community hospital in1998 were compared to a consecutive series of patients with acute pancreatitis from the same institution in 2008.
RESULTS: : Significantly more patients developed pancreatic necrosis; 26 (15%) of 173 patients in 1998 compared to 4 (4%) of 113 patients in 2008. The mean rate of hydration was significantly higher in 2008 compared with that in 1998 (P = 0.02). In 1998, hydration was provided at 184 mL/h during the first 6 hours and 188 mL/h during the first 12 hours compared with 284 mL/h during the first 6 hours and 221 mL/h during the first 12 hours in 2008. There was a significant decrease in mortality in 2008 compared with that in 1998 (3.5% vs 12%, P = 0.03).
CONCLUSIONS: : The decrease in mortality seen in patients with acute pancreatitis during the last decade may be related to the increased aggressive hydration preventing pancreatic necrosis.
Authors:
Ian Wall; Nison Badalov; Robin Baradarian; Kadirawel Iswara; Jian Jun Li; Scott Tenner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  40     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  547-50     Citation Subset:  IM    
Affiliation:
From the Division of Gastroenterology, Department of Medicine, Maimonides Medical Center, State University of New York - Health Sciences Center, Brooklyn, NY.
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