| Decreased memory for novel object recognition in chronically food-restricted mice is reversed by acute ghrelin administration. | |
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MedLine Citation:
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PMID: 18434026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been demonstrated, in normal and aged rats and mice, that acute i.c.v. ghrelin (Ghr) administration increases memory retention. In order to evaluate if this treatment, restores memory retention in animals exhibiting impaired memory, in the present work we selected a chronic food restriction mouse model (since undernutrition prejudices higher nervous functions). We employed adult female mice with 28 days of 50% food restriction and evaluated: a) behavioral performance using novel object recognition test for memory, and plus maze for anxiety-like behavior, b) some morphometric parameters as body and hepatic weights and c) plasma Ghr levels. The animals with 50% food restriction showed an increase in plasma Ghr levels and a decrease in morphometric parameters and in the percentage of novel object recognition time. When the peptide was i.c.v. injected in food-restricted animals (0.03, 0.3 or 3.0 nmol/microl), memory increases in relation to food-restricted mice injected with vehicle, reaching a performance similar to controls. |
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Authors:
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V P Carlini; A C Martini; H B Schiöth; R D Ruiz; M Fiol de Cuneo; S R de Barioglio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-20 |
Journal Detail:
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Title: Neuroscience Volume: 153 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-27 Completed Date: 2008-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 929-34 Citation Subset: IM |
Affiliation:
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Departamento de Farmacología, Facultad de Ciencias Químicas, Haya de la Torre y Medina Allende, Universidad Nacional de Córdoba, Ciudad Universitaria, 5016 Córdoba, Argentina. vcarlini@mail.fcq.unc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Behavior, Animal Body Weight / physiology Disease Models, Animal Dose-Response Relationship, Drug Exploratory Behavior / drug effects*, physiology Female Ghrelin / administration & dosage*, blood Liver / drug effects, physiology Maze Learning / drug effects Memory Disorders / drug therapy*, etiology*, pathology Mice Organ Size / drug effects, physiology Recognition (Psychology) / drug effects* Starvation / complications* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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