Document Detail

Decreased memory for novel object recognition in chronically food-restricted mice is reversed by acute ghrelin administration.
MedLine Citation:
PMID:  18434026     Owner:  NLM     Status:  MEDLINE    
It has been demonstrated, in normal and aged rats and mice, that acute i.c.v. ghrelin (Ghr) administration increases memory retention. In order to evaluate if this treatment, restores memory retention in animals exhibiting impaired memory, in the present work we selected a chronic food restriction mouse model (since undernutrition prejudices higher nervous functions). We employed adult female mice with 28 days of 50% food restriction and evaluated: a) behavioral performance using novel object recognition test for memory, and plus maze for anxiety-like behavior, b) some morphometric parameters as body and hepatic weights and c) plasma Ghr levels. The animals with 50% food restriction showed an increase in plasma Ghr levels and a decrease in morphometric parameters and in the percentage of novel object recognition time. When the peptide was i.c.v. injected in food-restricted animals (0.03, 0.3 or 3.0 nmol/microl), memory increases in relation to food-restricted mice injected with vehicle, reaching a performance similar to controls.
V P Carlini; A C Martini; H B Schiöth; R D Ruiz; M Fiol de Cuneo; S R de Barioglio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-20
Journal Detail:
Title:  Neuroscience     Volume:  153     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-27     Completed Date:  2008-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-34     Citation Subset:  IM    
Departamento de Farmacología, Facultad de Ciencias Químicas, Haya de la Torre y Medina Allende, Universidad Nacional de Córdoba, Ciudad Universitaria, 5016 Córdoba, Argentina.
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MeSH Terms
Analysis of Variance
Behavior, Animal
Body Weight / physiology
Disease Models, Animal
Dose-Response Relationship, Drug
Exploratory Behavior / drug effects*,  physiology
Ghrelin / administration & dosage*,  blood
Liver / drug effects,  physiology
Maze Learning / drug effects
Memory Disorders / drug therapy*,  etiology*,  pathology
Organ Size / drug effects,  physiology
Recognition (Psychology) / drug effects*
Starvation / complications*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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