| Decreased luteinizing hormone pulse frequency is associated with elevated 24-hour ghrelin after calorie restriction and exercise in premenopausal women. | |
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MedLine Citation:
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PMID: 23115078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevated ghrelin has been shown to be associated with reduced luteinizing hormone (LH) pulsatility in Rhesus monkeys, rats, men, and recently women. We previously reported that 24-h ghrelin concentrations are elevated in women following a 3-mo exercise and diet program leading to weight loss. We investigated whether the elevations in ghrelin following an ~3-mo exercise and diet program leading to weight loss are associated with a decrease in LH pulsatility. The nonexercising control group (Control, n = 5) consumed a controlled diet that matched energy needs, whereas energy intake in the exercise group (Energy Deficit, n = 16) was reduced from baseline energy requirements and supervised exercise training occurred five times per a week. Significant decreases in body weight (-3.0 ± 0.6 kg), body fat (-2.9 ± 0.4 kg) and 24-h LH pulse frequency (-0.18 ± 0.08 pulses/h), and a significant increase in 24-h mean ghrelin were observed in only the Energy Deficit group. The pre-post change in LH pulse frequency was negatively correlated with the change in mean 24-h ghrelin (R = -0.485, P = 0.030) and the change in peak ghrelin at lunch (R = -0.518, P = 0.019). Interestingly, pre-post change in night LH pulse frequency was negatively correlated with the change in mean day ghrelin (R = -0.704, P = 0.001). Elevated total ghrelin concentrations are associated with the suppression of LH pulsatility in premenopausal women and may play a role in the suppression of reproductive function following weight loss. |
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Authors:
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Jennifer L Scheid; Mary Jane De Souza; Brenna R Hill; Heather J Leidy; Nancy I Williams |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-10-31 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 304 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: 2013-02-27 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E109-16 Citation Subset: IM |
Affiliation:
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Women's Health and Exercise Laboratory, Noll Laboratory, Dept. of Kinesiology, Penn State University, University Park, PA 16802, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Body Composition / physiology Caloric Restriction* Circadian Rhythm / physiology Down-Regulation / physiology Exercise / physiology* Female Ghrelin / blood* Humans Luteinizing Hormone / blood, secretion* Premenopause* / blood, physiology Pulsatile Flow Up-Regulation / physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1R01 HD-39245-01A1/HD/NICHD NIH HHS; M01 RR-10732/RR/NCRR NIH HHS; //Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 9002-67-9/Luteinizing Hormone |
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