Document Detail


Decreased luteinizing hormone pulse frequency is associated with elevated 24-hour ghrelin after calorie restriction and exercise in premenopausal women.
MedLine Citation:
PMID:  23115078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elevated ghrelin has been shown to be associated with reduced luteinizing hormone (LH) pulsatility in Rhesus monkeys, rats, men, and recently women. We previously reported that 24-h ghrelin concentrations are elevated in women following a 3-mo exercise and diet program leading to weight loss. We investigated whether the elevations in ghrelin following an ~3-mo exercise and diet program leading to weight loss are associated with a decrease in LH pulsatility. The nonexercising control group (Control, n = 5) consumed a controlled diet that matched energy needs, whereas energy intake in the exercise group (Energy Deficit, n = 16) was reduced from baseline energy requirements and supervised exercise training occurred five times per a week. Significant decreases in body weight (-3.0 ± 0.6 kg), body fat (-2.9 ± 0.4 kg) and 24-h LH pulse frequency (-0.18 ± 0.08 pulses/h), and a significant increase in 24-h mean ghrelin were observed in only the Energy Deficit group. The pre-post change in LH pulse frequency was negatively correlated with the change in mean 24-h ghrelin (R = -0.485, P = 0.030) and the change in peak ghrelin at lunch (R = -0.518, P = 0.019). Interestingly, pre-post change in night LH pulse frequency was negatively correlated with the change in mean day ghrelin (R = -0.704, P = 0.001). Elevated total ghrelin concentrations are associated with the suppression of LH pulsatility in premenopausal women and may play a role in the suppression of reproductive function following weight loss.
Authors:
Jennifer L Scheid; Mary Jane De Souza; Brenna R Hill; Heather J Leidy; Nancy I Williams
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-31
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  304     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-02-27     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E109-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Body Composition / physiology
Caloric Restriction*
Circadian Rhythm / physiology
Down-Regulation / physiology
Exercise / physiology*
Female
Ghrelin / blood*
Humans
Luteinizing Hormone / blood,  secretion*
Premenopause* / blood,  physiology
Pulsatile Flow
Up-Regulation / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
1R01 HD-39245-01A1/HD/NICHD NIH HHS; M01 RR-10732/RR/NCRR NIH HHS; //Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Ghrelin; 9002-67-9/Luteinizing Hormone
Comments/Corrections

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