Document Detail


Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma.
MedLine Citation:
PMID:  21878241     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Preschool rhinovirus (RV) wheezing illnesses predict an increased risk of childhood asthma; however, it is not clear how specific viral illnesses in early life relate to lung function later on in childhood.
OBJECTIVE: To determine the relationship of virus-specific wheezing illnesses and lung function in a longitudinal cohort of children at risk for asthma.
METHODS: Two hundred thirty-eight children were followed prospectively from birth to 8 years of age. Early life viral wheezing respiratory illnesses were assessed by using standard techniques, and lung function was assessed annually by using spirometry and impulse oscillometry. The relationships of these virus-specific wheezing illnesses and lung function were assessed by using mixed-effect linear regression.
RESULTS: Children with RV wheezing illness demonstrated significantly decreased spirometry values, FEV(1) (P = .001), FEV(0.5) (P < .001), FEF(25-75) (P < .001), and also had abnormal impulse oscillometry measures--more negative reactance at 5 Hz (P < .001)--compared with those who did not wheeze with RV. Children who wheezed with respiratory syncytial virus or other viral illnesses did not have any significant differences in spirometric or impulse oscillometry indices when compared with children who did not. Children diagnosed with asthma at ages 6 or 8 years had significantly decreased FEF(25-75) (P = .05) compared with children without asthma.
CONCLUSION: Among outpatient viral wheezing illnesses in early childhood, those caused by RV infections are the most significant predictors of decreased lung function up to age 8 years in a high-risk birth cohort. Whether low lung function is a cause and/or effect of RV wheezing illnesses is yet to be determined.
Authors:
Theresa W Guilbert; Anne Marie Singh; Zoran Danov; Michael D Evans; Daniel J Jackson; Ryan Burton; Kathy A Roberg; Elizabeth L Anderson; Tressa E Pappas; Ronald Gangnon; James E Gern; Robert F Lemanske
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  128     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-31     Completed Date:  2011-11-15     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  532-8.e1-10     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Asthma / diagnosis*,  etiology,  physiopathology
Child
Child, Preschool
Cohort Studies
Female
Humans
Longitudinal Studies
Lung / physiopathology
Male
Oscillometry
Picornaviridae Infections / complications*,  virology
Respiratory Function Tests
Respiratory Sounds / etiology*
Rhinovirus / pathogenicity*
Risk
Spirometry
Grant Support
ID/Acronym/Agency:
M01 RR003186/RR/NCRR NIH HHS; M01 RR003186-14/RR/NCRR NIH HHS; M01 RR03186/RR/NCRR NIH HHS; P01 HL070831/HL/NHLBI NIH HHS; P01 HL070831-05/HL/NHLBI NIH HHS; P01 HL70831/HL/NHLBI NIH HHS; R01 HL061879/HL/NHLBI NIH HHS; R01 HL061879-04/HL/NHLBI NIH HHS; R01 HL61879/HL/NHLBI NIH HHS; UL1 RR025011/RR/NCRR NIH HHS; UL1 RR025011-05/RR/NCRR NIH HHS
Comments/Corrections
Comment In:
J Allergy Clin Immunol. 2012 Jan;129(1):267-8; author reply 268   [PMID:  22078470 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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