Document Detail


Decreased lithium clearance in patients with hyperthyroidism.
MedLine Citation:
PMID:  8502334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lithium clearance was studied to investigate proximal tubular function in patients with hyperthyroidism (n = 10) and control subjects (n = 7). Patients with hyperthyroidism showed significantly reduced fractional excretion of lithium (FELi) compared with control subjects (15.0 +/- 1.5%, n = 10, vs. 23.7 +/- 0.6%, n = 7, means +/- SE, p < 0.001). The reduced FELi of the hyperthyroid state was reversed toward control values with treatment by antithyroid drugs (12.6 +/- 2.6 toward 26.8 +/- 2.5% for 5 patients, means +/- SE). Tubular reabsorption of phosphate (TRP) was significantly increased in hyperthyroid patients compared with control subjects (96.1 +/- 0.7 vs. 87.5 +/- 0.7%, p < 0.001), and it returned to control values after the treatment. Our data demonstrate that lithium clearance is decreased and TRP is increased in patients with hyperthyroidism, which suggests that proximal tubular reabsorption of sodium and TRP is increased in hyperthyroidism.
Authors:
A Owada; K Tomita; K Ujiie; T Akiba; F Marumo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephron     Volume:  64     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1993  
Date Detail:
Created Date:  1993-06-29     Completed Date:  1993-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  37-41     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Humans
Hyperthyroidism / drug therapy,  metabolism*
Kidney Tubules, Proximal / metabolism
Lithium / pharmacokinetics*
Metabolic Clearance Rate
Middle Aged
Phosphates / metabolism
Sodium / metabolism
Thyroxine / blood
Chemical
Reg. No./Substance:
0/Phosphates; 7439-93-2/Lithium; 7440-23-5/Sodium; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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