| Decreased lithium clearance in patients with hyperthyroidism. | |
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MedLine Citation:
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PMID: 8502334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lithium clearance was studied to investigate proximal tubular function in patients with hyperthyroidism (n = 10) and control subjects (n = 7). Patients with hyperthyroidism showed significantly reduced fractional excretion of lithium (FELi) compared with control subjects (15.0 +/- 1.5%, n = 10, vs. 23.7 +/- 0.6%, n = 7, means +/- SE, p < 0.001). The reduced FELi of the hyperthyroid state was reversed toward control values with treatment by antithyroid drugs (12.6 +/- 2.6 toward 26.8 +/- 2.5% for 5 patients, means +/- SE). Tubular reabsorption of phosphate (TRP) was significantly increased in hyperthyroid patients compared with control subjects (96.1 +/- 0.7 vs. 87.5 +/- 0.7%, p < 0.001), and it returned to control values after the treatment. Our data demonstrate that lithium clearance is decreased and TRP is increased in patients with hyperthyroidism, which suggests that proximal tubular reabsorption of sodium and TRP is increased in hyperthyroidism. |
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Authors:
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A Owada; K Tomita; K Ujiie; T Akiba; F Marumo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nephron Volume: 64 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1993 |
Date Detail:
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Created Date: 1993-06-29 Completed Date: 1993-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 37-41 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Humans Hyperthyroidism / drug therapy, metabolism* Kidney Tubules, Proximal / metabolism Lithium / pharmacokinetics* Metabolic Clearance Rate Middle Aged Phosphates / metabolism Sodium / metabolism Thyroxine / blood |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 7439-93-2/Lithium; 7440-23-5/Sodium; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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