Document Detail

Decreased lipid intake reduces morbidity in sick premature neonates.
MedLine Citation:
PMID:  3142984     Owner:  NLM     Status:  MEDLINE    
For an investigation of the clinical sequelae of parenteral lipid infusions during the first week of life, 42 neonates (less than 1750 gm birth weight) were randomly assigned to receive parenteral alimentation with (IL) (Vitrum) or without a parenteral lipid infusion (NL) for 5 days. Follow-up clinical status was monitored and compared, and plasma prostaglandin levels were analyzed. Chronic lung disease was increased in duration and tended to be more severe after lipid administration. The number of days of mechanical ventilation (37 +/- 35 vs 21 +/- 18) and supplemental oxygen therapy (51 +/- 39 vs 28 +/- 23) was significantly increased in the IL group. Five IL infants developed stage 3 bronchopulmonary dysplasia, in comparison with none of the NL infants. Seven IL infants were discharged on a regimen of supplemental oxygen therapy versus none of the NL infants. Thromboxane B2 levels were significantly increased in the babies receiving Vitrum. We conclude that early administration of Vitrum in the premature neonate is associated with increased respiratory difficulty in the ensuing weeks of life.
C Hammerman; M J Aramburo
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  113     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-10     Completed Date:  1989-01-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1083-8     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Chicago, IL 60637.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / blood
Clinical Trials as Topic
Double-Blind Method
Fat Emulsions, Intravenous / administration & dosage*
Infant, Newborn
Infant, Premature, Diseases / therapy*
Oxygen / blood
Parenteral Nutrition, Total*
Prostaglandins / blood*
Random Allocation
Thromboxane B2 / blood
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Prostaglandins; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 7782-44-7/Oxygen
Comment In:
J Pediatr. 1989 Aug;115(2):331-2   [PMID:  2818721 ]
J Pediatr. 1989 Jun;114(6):1070-1   [PMID:  2723906 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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