| Decreased likelihood of response to cardiac resynchronization in patients with severe heart failure. | |
| | |
MedLine Citation:
|
PMID: 20156941 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: We hypothesized that a very advanced stage of dilated cardiomyopathy is associated with lower response to cardiac resynchronization therapy (CRT). METHODS AND RESULTS: A consecutive cohort of 147 patients was studied before device implantation and at 12 months follow-up. All patients were in NYHA functional class III-IV and had left-ventricular (LV) systolic dysfunction (LV ejection fraction 24 +/- 7%) and a wide QRS (171 +/- 29 ms). A patient who was alive without heart transplantation and had improved by at least 10% in the 6 min walking test at 12 months follow-up was considered a clinical responder. Fifty-four patients (36%) did not respond to CRT (15 cardiac deaths, 4 heart transplantations). Quality of life indicators (>41 points), LV end-diastolic volumes (>200 mL) and mitral regurgitant orifice area (>16 mm(2)) at baseline were independent predictors of response to CRT. Patients were assigned 1 point for each predictive parameter. Patients with higher scores showed a significantly higher likelihood of non-response to CRT (chi(2) = 12 891, P = 0.005). CONCLUSION: The results show that non-responder patients have a more advanced stage of the disease, which suggests that CRT should be indicated earlier in the disease process. |
| | |
Authors:
|
Bàrbara Vidal; Victoria Delgado; Lluís Mont; Sílvia Poyatos; Etelvino Silva; María Angeles Castel; José M Tolosana; Antonio Berruezo; Josep Brugada; Marta Sitges |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-16 Completed Date: 2010-06-10 Revised Date: 2011-06-08 |
Medline Journal Info:
|
Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 283-7 Citation Subset: IM |
Affiliation:
|
Thorax Clinic Institute, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Villarroel 136, 08036 Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cardiac Pacing, Artificial* Cohort Studies Confidence Intervals Disease Progression Female Heart Failure / therapy*, ultrasonography Humans Logistic Models Male Multivariate Analysis Odds Ratio Quality of Life Questionnaires Sensitivity and Specificity Severity of Illness Index Time Factors Treatment Outcome Ventricular Dysfunction, Left / therapy*, ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characteristics, outcomes, and predictors of mortality at 3 months and 1 year in patients hospitaliz...
Next Document: Extracorporeal membrane oxygenation as a rescue of intractable ventricular fibrillation and bridge t...