Document Detail

Decreased liberation of noradrenaline from the heart following cold crystalloid cardioplegia.
MedLine Citation:
PMID:  1947909     Owner:  NLM     Status:  MEDLINE    
Exogenous catecholamine support is often needed soon after termination of cardiopulmonary bypass even when appropriate cardioplegia has been used. To study the effect of hypothermic cardioplegic ischemia and reperfusion on the activity of the cardiac sympathetic nervous system, plasma noradrenaline concentration in the coronary sinus and general circulation was measured in six patients undergoing valve replacement for nonischemic mitral disease. Before cardiopulmonary bypass and cardioplegia the release of noradrenaline from the heart was greater than the mean systemic release. After ischemia, during reperfusion, the heart tended to extract noradrenaline, and 10 min after termination of bypass the plasma noradrenaline gradient over the heart remained less than pre-bypass. The results indicated decreased activity of the cardiac sympathetic nervous system, which may explain the frequent need for catecholamine support.
L Bengtsson; A Henze; L O Farnebo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of thoracic and cardiovascular surgery     Volume:  25     ISSN:  0036-5580     ISO Abbreviation:  Scand J Thorac Cardiovasc Surg     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-20     Completed Date:  1991-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121343     Medline TA:  Scand J Thorac Cardiovasc Surg     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  147-50     Citation Subset:  IM    
Department of Thoracic and Cardiovascular Surgery, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Cardiopulmonary Bypass
Heart / innervation*
Heart Arrest, Induced*
Heart Valve Prosthesis
Intraoperative Care
Isotonic Solutions
Middle Aged
Myocardial Reperfusion*
Norepinephrine / metabolism*
Plasma Substitutes
Sympathetic Nervous System / physiology*
Reg. No./Substance:
0/Isotonic Solutions; 0/Plasma Substitutes; 0/crystalloid solutions; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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