Document Detail


Decreased levels of soluble intercellular adhesion molecule-1 (sICAM-1) in unmedicated and medicated schizophrenic patients.
MedLine Citation:
PMID:  10650446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The soluble intercellular adhesion molecule-1 (sICAM-1) is a marker for the activation of the cellular immune system. Since an activation of the immune system has been observed in a part of the schizophrenic patients, we measured the serum levels of soluble ICAM-1 (sICAM-1) in schizophrenic patients and correlated them to the patient's psychopathology. METHODS: To monitor a possible effect of antipsychotic therapy, 36 schizophrenic patients were examined twice: first without antipsychotic medication immediately after admission to the hospital and then, after clinical improvement before discharge. The results were compared with those of 36 age- and gender-related healthy individuals. RESULTS: The schizophrenic patients showed significantly decreased serum levels of sICAM-1 at the first examination (248 +/- 95 ng/mL) and at re-examination (266 +/- 95 ng/mL) compared with the comparison group (323 +/- 74 ng/mL). Patients with more pronounced negative symptoms showed higher levels of sICAM-1 at the first examination. CONCLUSIONS: We conclude that reduced sICAM-1 levels in schizophrenia indicate a reduced activity of the cellular immune system in at least a subgroup of schizophrenic patients.
Authors:
M J Schwarz; M Riedel; M Ackenheil; N Müller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  47     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-08     Completed Date:  2000-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  IM    
Affiliation:
Psychiatric Hospital, Ludwig-Maximilian University, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Antipsychotic Agents / therapeutic use
Blood-Brain Barrier / immunology*
Case-Control Studies
Female
Humans
Immunity, Cellular
Intercellular Adhesion Molecule-1 / blood*,  immunology
Male
Middle Aged
Psychiatric Status Rating Scales
Remission Induction
Schizophrenia / blood,  drug therapy,  immunology*
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 126547-89-5/Intercellular Adhesion Molecule-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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