Document Detail


Decreased levels of plasma glutamate in patients with first-episode schizophrenia and bipolar disorder.
MedLine Citation:
PMID:  17630258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A variety of studies have suggested that glutamatergic neurotransmission is altered in schizophrenia and bipolar disorder. Here, we tested if plasma glutamate levels are altered in 56 patients diagnosed with schizophrenia, bipolar disorder or non-specified psychosis at the first psychotic episode and at various stages during one-year follow-up. A decrease in the levels of plasma glutamate was observed in all groups of patients at the first psychotic episode. Furthermore, plasma glutamate levels were restored after treatment in all instances. Decreased plasma glutamate levels at first psychotic episodes may reflect impaired glutamate signaling during the initial stages of schizophrenia and bipolar disorder.
Authors:
Aitor Palomino; Ana González-Pinto; Ana Aldama; Cristina González-Gómez; Fernando Mosquera; Gixane González-García; Carlos Matute
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-13
Journal Detail:
Title:  Schizophrenia research     Volume:  95     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-03     Completed Date:  2007-10-24     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  174-8     Citation Subset:  IM    
Affiliation:
Neurotek UPV-EHU, Parque Tecnológico de Bizkaia, E-48170 Zamudio, Vizcaya, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Transport System X-AG / drug effects,  physiology
Antipsychotic Agents / pharmacology,  therapeutic use
Bipolar Disorder / blood*,  drug therapy,  physiopathology
Female
Follow-Up Studies
Glutamates / blood*,  drug effects,  physiology
Humans
Longitudinal Studies
Male
Psychiatric Status Rating Scales / statistics & numerical data
Psychotic Disorders / blood,  drug therapy,  physiopathology
Schizophrenia / blood*,  drug therapy,  physiopathology
Synaptic Transmission / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Amino Acid Transport System X-AG; 0/Antipsychotic Agents; 0/Glutamates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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