Document Detail

Decreased levels of peritoneal interleukin-1 receptor antagonist in patients with endometriosis and disease-related dysmenorrhea.
MedLine Citation:
PMID:  17292896     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the level of interleukin-1 receptor antagonist (IL-1ra) in peritoneal fluid (PF) and serum in patients with endometriosis. DESIGN: A prospective analytical study. SETTING: University-affiliated obstetrics and gynecology academic training hospital. PATIENT(S): One hundred eighteen patients underwent laparoscopy for benign gynecologic diseases. INTERVENTION(S): Peripheral blood and PF were obtained before and during surgical procedures, and the levels of IL-1ra were measured. MAIN OUTCOME MEASURE(S): The concentrations of IL-1ra in PF and serum were correlated with the presence of endometriosis, disease stage, and the phase of menstrual cycle. RESULT(S): Peritoneal fluid IL-1ra concentrations were significantly lower in patients with endometriosis than in patients without endometriosis. Peritoneal fluid IL-1ra concentrations decreased with the increased severity of endometriosis and also decreased in disease-related dysmenorrhea; serum IL-1ra levels showed no significant difference between the patients with and without endometriosis. The concentrations of IL-1ra in PF and serum were not correlated with the phase of menstrual cycle. CONCLUSION(S): Our results suggested that decreased levels of PF IL-1ra in patients with endometriosis and disease-related dysmenorrhea may play an important role in the pathogenesis of this disease.
Xinmei Zhang; Jie Wen; Lin Deng; Jun Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-12
Journal Detail:
Title:  Fertility and sterility     Volume:  88     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-11     Completed Date:  2007-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  594-9     Citation Subset:  IM    
Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
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MeSH Terms
Abortion, Spontaneous / epidemiology
Dysmenorrhea / pathology*
Endometriosis / pathology*
Interleukin 1 Receptor Antagonist Protein / metabolism*
Interleukin-1beta / metabolism
Sterilization, Tubal
Reg. No./Substance:
0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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