Document Detail


Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function.
MedLine Citation:
PMID:  10586185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Airway S-nitrosothiols (SNOs) are naturally occurring bronchodilators. SNOs, nitrate, and nitrite were measured in bronchoalveolar lavage fluid of 23 patients with cystic fibrosis (CF) and mild pulmonary disease (aged 6-16 years) and 13 healthy children (aged 8-15 years). Concentrations of SNOs were decreased in the lower airways of patients with CF and mild pulmonary disease (median, range: 0, 0-320 nmol/L vs 80, 0-970 nmol/L) despite normal levels of the inert nitric oxide metabolites nitrate and nitrite (mean +/- SEM: 3.7 +/- 0.5 micromol/L vs 4.8 +/- 0.9 micromol/L). S-nitrosolation- mediated bioreactivities may be impaired by depletion of the CF airway SNO reservoir.
Authors:
H Grasemann; B Gaston; K Fang; K Paul; F Ratjen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  135     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-12-30     Completed Date:  1999-12-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  770-2     Citation Subset:  AIM; IM    
Affiliation:
Children's Hospital, University of Essen, Essen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Bronchi / chemistry*
Bronchoalveolar Lavage Fluid
Child
Cystic Fibrosis / metabolism*,  physiopathology
Humans
Mercaptoethanol*
Nitroso Compounds / analysis*
Respiratory Function Tests
S-Nitrosothiols*
Chemical
Reg. No./Substance:
0/Nitroso Compounds; 0/S-Nitrosothiols; 60-24-2/Mercaptoethanol; 67616-44-8/S-nitrosomercaptoethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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