Document Detail


Decreased levels of glia-derived nexin/protease nexin I in irradiated rat spinal cord in vivo.
MedLine Citation:
PMID:  8373421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathophysiology of the cellular basis of radiation induced demyelination and white matter necrosis of the Central Nervous System (CNS) is poorly understood. There have been no previous studies that have shown the effect of irradiation on glia-derived nexin. In this study, rats were given cervical spinal cord irradiation, and glial derived nexin or protease nexin I (GDN/PNI) was measured on days 2, 7, 30, 60, 120, 130, and 145 after irradiation. The level of GDN/PNI significantly decreased after irradiation compared to levels in control spinal cord, and there was no detectable levels of GDN/PNI by the time paralysis developed. This study adds considerable weight to the proposal that GDN/PNI has an important role in the pathogenesis of CNS radiation damage.
Authors:
J S Rao; S Kono; A Rayford; K K Ang; Y Feng; D Monard; R Sawaya
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  195     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-10-12     Completed Date:  1993-10-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  853-8     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, University of Texas M. D. Anderson Cancer Center, Houston 77030.
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MeSH Terms
Descriptor/Qualifier:
Amyloid beta-Protein Precursor
Animals
Blotting, Western
Carrier Proteins / isolation & purification,  metabolism*,  radiation effects
Neuroglia / metabolism,  radiation effects*
Rats
Receptors, Cell Surface
Serpins / metabolism*,  radiation effects
Spinal Cord / metabolism,  radiation effects*
Time Factors
Grant Support
ID/Acronym/Agency:
NCI CA-16672/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein Precursor; 0/Carrier Proteins; 0/Receptors, Cell Surface; 0/Serpins; 0/protease nexins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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