| Decreased levels of glia-derived nexin/protease nexin I in irradiated rat spinal cord in vivo. | |
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MedLine Citation:
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PMID: 8373421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathophysiology of the cellular basis of radiation induced demyelination and white matter necrosis of the Central Nervous System (CNS) is poorly understood. There have been no previous studies that have shown the effect of irradiation on glia-derived nexin. In this study, rats were given cervical spinal cord irradiation, and glial derived nexin or protease nexin I (GDN/PNI) was measured on days 2, 7, 30, 60, 120, 130, and 145 after irradiation. The level of GDN/PNI significantly decreased after irradiation compared to levels in control spinal cord, and there was no detectable levels of GDN/PNI by the time paralysis developed. This study adds considerable weight to the proposal that GDN/PNI has an important role in the pathogenesis of CNS radiation damage. |
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Authors:
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J S Rao; S Kono; A Rayford; K K Ang; Y Feng; D Monard; R Sawaya |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 195 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1993 Sep |
Date Detail:
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Created Date: 1993-10-12 Completed Date: 1993-10-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 853-8 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University of Texas M. D. Anderson Cancer Center, Houston 77030. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyloid beta-Protein Precursor Animals Blotting, Western Carrier Proteins / isolation & purification, metabolism*, radiation effects Neuroglia / metabolism, radiation effects* Rats Receptors, Cell Surface Serpins / metabolism*, radiation effects Spinal Cord / metabolism, radiation effects* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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NCI CA-16672/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein Precursor; 0/Carrier Proteins; 0/Receptors, Cell Surface; 0/Serpins; 0/protease nexins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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