Document Detail


Decreased leg glucose uptake during exercise contributes to the hyperglycaemic effect of octreotide.
MedLine Citation:
PMID:  20132129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: During prolonged infusion of somatostatin, there is an increase in arterial glucose concentration, and this increase persists even during prolonged exercise. The aim of the study was to measure glucose uptake in the leg muscles during infusion of the somatostatin analogue octreotide before and during leg exercise. MATERIAL AND METHODS: Eight healthy male subjects were investigated twice in the fasting state: during 3 h infusion of octreotide [30 ng (kg min)(-1)] or sodium chloride with exercise at 50% of maximal VO(2) in the last hour. Glucose uptake and oxygen uptake in the leg were measured using Fick's principle by blood sampling from an artery and a femoral vein. Blood flow in the leg was measured using the indicator (indocyanine green) dilution technique. RESULTS: After an initial decrease during rest, octreotide infusion resulted in a significant increase in arterial glucose concentrations compared to control conditions during exercise (mean +/- SEM: 7.6 +/- 0.6 versus 5.6 +/- 0.1 mmol l(-1), P<0.01). During rest, octreotide did not change the leg glucose uptake (59 +/- 10 versus 55 +/- 11 micromol min(-1)). In contrast, leg glucose uptake was significantly lower during exercise compared to control conditions (208 +/- 79 versus 423 +/- 87 micromol min(-1), P<0.05). During exercise, leg oxygen uptake was not different in the two experiments (20.4 +/- 1.3 versus 19.5 +/- 1.1 micromol min(-1)). CONCLUSION: In conclusion, infusion of octreotide reduced leg glucose uptake during exercise, despite the same leg oxygen consumption and blood flow compared to control conditions. The hyperglycaemic effect of octreotide can partly be explained by the reduction in leg glucose uptake. Furthermore, the results suggest that a certain level of circulating insulin is necessary to obtain sufficient stimulation of glucose uptake in the exercising muscles.
Authors:
Peter Hovind; Lene Simonsen; Jens Bülow
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-01-28
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  30     ISSN:  1475-097X     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / drug effects*,  metabolism*
Exercise / physiology*
Femoral Artery
Femoral Vein
Gastrointestinal Agents / administration & dosage,  adverse effects
Humans
Hyperglycemia / chemically induced*,  metabolism*
Insulin / blood
Leg / blood supply,  physiology
Male
Middle Aged
Octreotide / administration & dosage,  adverse effects*
Oxygen Consumption / physiology
Pulmonary Gas Exchange / physiology
Regional Blood Flow / physiology
Young Adult
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Gastrointestinal Agents; 11061-68-0/Insulin; 83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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