Document Detail


Decreased large artery distensibility in borderline hypertension is related to increased in vivo low-density lipoprotein oxidation.
MedLine Citation:
PMID:  12476929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study tested the hypothesis that reduced arterial elasticity seen in hypertension is related to increased oxidation of LDL. Fifteen men with borderline hypertension (BHT), with blood pressure values classified as high normal (systolic blood pressure 130-140 mmHg or diastolic blood pressure 85-89 mmHg) were included. The control group comprised 22 men with normal blood pressure values (<135/80 mmHg) matched for age, body size and LDL-cholesterol level. Distensibility of aorta was measured using magnetic resonance imaging, and distensibility of the common carotid artery using ultrasound. Baseline LDL diene conjugation was used as a marker for ox-LDL. Aortic and carotid distensibilities were lower in the BHT men than in controls (1.4 +/- 0.6 vs. 1.9 +/- 0.6%/10 mmHg, p<0.05 for aortic distensibility; 2.9 +/- 0.9 vs. 3.6 +/- 0.6%/10 mmHg, p<0.05 for carotid distensibility). Ox-LDL was significantly higher in the BHT men than in controls (44 +/-15 vs. 28 +/- 8 micromol/L, p<0.01). In univariate analysis, ox-LDL associated with aortic distensibility (r=-0.43, p<0.05). In multivariate analysis, the differences in distensibilities between the groups disappeared when the values were adjusted for ox-LDL. These data show decreased arterial elasticity and increased LDL oxidation in young men with borderline hypertension, and suggest that oxidative modification of LDL particles may play a pathophysiological role in the development of reduced arterial distensibility in hypertension.
Authors:
J O Toikka; P Niemi; M Ahotupa; H Niinikoski; T Rönnemaa; J S A Viikari; J J Hartiala; O T Raitakari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  62     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2002  
Date Detail:
Created Date:  2002-12-12     Completed Date:  2003-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology, Turku University Central Hospital, Finland. jyri.toikka@utu.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Aorta / physiopathology*
Blood Pressure
Brachial Artery / physiopathology
Carotid Artery, Common / physiopathology,  ultrasonography
Elasticity
Humans
Hypertension / metabolism*,  physiopathology*,  ultrasonography
Lipoproteins, LDL / metabolism*
Magnetic Resonance Imaging
Male
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Lipoproteins, LDL; 0/oxidized low density lipoprotein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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