Document Detail

Decreased interleukin-2 production in Korean schizophrenic patients.
MedLine Citation:
PMID:  9583005     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been postulated that autoimmune process may play a role in the pathogenesis of symptoms in some schizophrenic patients. Findings of altered interleukin (IL) regulation have been regarded as additional proof that schizophrenia has an autoimmunological background. METHODS: Sixteen patients who fulfilled DSM-IV criteria for schizophrenia and who were drug free for at least six months and the same number of age- and sex-matched controls were recruited. The severity of symptoms in schizophrenia was assessed by BPRS. Phytohemagglutinin (PHA)-stimulated production and serum level of IL-1 beta, IL-2, and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: There was a significant decrease of IL-2 production (p < .01) in schizophrenic patients and a significant increase of IL-2 serum level (p < .01). No significant difference of IL-1 beta and IL-6 was found. Some patients and controls had measurable serum level of IL-1 beta and IL-6. No significant correlation between production and serum level of IL-1 beta, -2, -6 and age, duration of illness, and BPRS score in schizophrenics was found. CONCLUSIONS: This is the first study to describe a decrease of IL-2 production and increase of IL-2 serum level in non-Caucasian schizophrenic patients. These findings are further evidence that autoimmune process is present, regardless of ethnic origin, in some schizophrenic patients.
Y K Kim; M S Lee; K Y Suh
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  43     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-26     Completed Date:  1998-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  701-4     Citation Subset:  IM    
Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea.
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MeSH Terms
Enzyme-Linked Immunosorbent Assay
Interleukin-1 / biosynthesis,  blood
Interleukin-2 / biosynthesis*,  blood
Interleukin-6 / biosynthesis,  blood
Phytohemagglutinins / diagnostic use
Schizophrenia / blood,  metabolism*
Reg. No./Substance:
0/Interleukin-1; 0/Interleukin-2; 0/Interleukin-6; 0/Phytohemagglutinins

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