| Decreased incidence of lupus nephritis in northern Norway is linked to increased use of antihypertensive and anticoagulant therapy. | |
| | |
MedLine Citation:
|
PMID: 20647194 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
METHODS: This is an observational study of two subsequent SLE inception cohorts based on 1982 American College of Rheumatology (acr) classification criteria (82acr; n = 87, enrolled 1978-95) and the updated version in 1997 (97acr: n = 62, enrolled 1996-2006). Annual incidence rates (AIR), point prevalence, clinical and histological features, and outcome of LN (defined as proteinuria with urinary casts and/or haematuria) were compared between both cohorts. RESULTS: Between 1978 and 2006, the AIR for LN decreased from 0.7 to 0.45/100 000, while LN prevalence rose from 7 to 14/100 000. The relative risk reduction in the 97acr for early- and late-onset LN (> 3 months after SLE diagnosis) was 39% and 42%, respectively. Patients developing LN in the 97acr cohort (97LN +; n = 11) had similar demographics, more often low avidity anti-dsDNA antibodies (Ab) and/or anti-cardiolipin Ab at SLE diagnosis, lower proteinuria and diastolic blood pressure, and similar histological findings to those in the 83acr cohort (82LN +; n = 28). Following LN diagnosis, more 97LN + patients received pulse corticosteroids (55% vs. 7%), anticoagulants (46% vs. 4%) and antihypertensive drugs (46% vs. 11%). Three 82LN + patients (11%) developed end-stage renal disease versus none in 97LN + during a 10-year follow-up. CONCLUSIONS: Early detection of low avidity anti-dsDNA and antiphospholipid antibodies, probably in combination with early use of protective cardiovascular measures from SLE diagnosis onwards may contribute to reduced incidence and improved renal survival in LN. |
| | |
Authors:
|
Gro Østli Eilertsen; Silje Fismen; Tor-Arne Hanssen; Johannes C Nossent |
Related Documents
:
|
9187214 - Acute lupus pneumonitis with normal chest radiograph. 17728364 - Oral health and the masticatory system in juvenile systemic lupus erythematosus. 8164214 - Antinuclear antibodies and connective tissue disease features in fibromyalgia syndrome:... 380854 - Antibodies to histones in systemic lupus erythematosus. 17238494 - Ehand-offs: an ibm lotus domino application for ensuring patient safety and enhancing r... 8309754 - Spinal deformities in deferoxamine-treated homozygous beta-thalassemia major patients. |
Publication Detail:
|
Type: Journal Article Date: 2010-07-19 |
Journal Detail:
|
Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 26 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
|
Languages: eng Pagination: 620-7 Citation Subset: IM |
Affiliation:
|
Correspondence and offprint requests to: Gro Østli Eilertsen; E-mail: gro.ostli.eilertsen@unn.no. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Can mycophenolic acid dose requirement during the first transplant help predict dosing for the secon...
Next Document: Paget-schroetter syndrome.