Document Detail


Decreased heart rate variability predicts death in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  22907223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Some patients with amyotrophic lateral sclerosis (ALS) die suddenly despite normal nocturnal pulse oximetry (NPO), possibly due to dysautonomia.
METHODS: Forty-four ALS patients without other medical conditions were studied. Heart rate variability was assessed through finger oximetry. The heart rate coefficient of variation (HR CV) was evaluated during nocturnal sleep. All patients were investigated at study entry (T1); 13 were tested 4 months later (T2), and 21 patients were investigated a further 24 months after entry (T3). Only recordings obtained from patients with normal NPO were accepted.
RESULTS: HR maximal, minimum, and median values remained stable. HR CV was similar between T1 and T2, but it decreased significantly at T3 (P < 0.01). Very low values were observed in 4 patients at T3 (HR CV <0.20), and 3 died suddenly within the following 2 months, despite normal NPO.
CONCLUSIONS: Low HR CV is a potential marker of prognosis in ALS.
Authors:
Susana Pinto; Anabela Pinto; Mamede De Carvalho
Related Documents :
21604063 - Renal function assessment in patients with systemic lupus erythematosus.
20178533 - Vaginal intraepithelial neoplasia: a retrospective analysis of clinical features and co...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  46     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-21     Completed Date:  2012-11-06     Revised Date:  2013-05-01    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Neuromuscular Unit, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amyotrophic Lateral Sclerosis / complications,  physiopathology*
Death, Sudden*
Diaphragm / physiopathology
Female
Heart Rate / physiology*
Humans
Male
Middle Aged
Oximetry*
Predictive Value of Tests
Prognosis
Prospective Studies
Respiratory Insufficiency / etiology,  physiopathology*
Retrospective Studies
Comments/Corrections
Comment In:
Muscle Nerve. 2013 Apr;47(4):619-20   [PMID:  23456801 ]
Muscle Nerve. 2013 Apr;47(4):620-1   [PMID:  23456793 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fibrillation potential onset in peripheral nerve injury.
Next Document:  MUAP values of two facial muscles in normal subjects and comparison of two methods for data analysis...