Document Detail

Decreased heart rate variability predicts death in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  22907223     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Some patients with amyotrophic lateral sclerosis (ALS) die suddenly despite normal nocturnal pulse oximetry (NPO), possibly due to dysautonomia.
METHODS: Forty-four ALS patients without other medical conditions were studied. Heart rate variability was assessed through finger oximetry. The heart rate coefficient of variation (HR CV) was evaluated during nocturnal sleep. All patients were investigated at study entry (T1); 13 were tested 4 months later (T2), and 21 patients were investigated a further 24 months after entry (T3). Only recordings obtained from patients with normal NPO were accepted.
RESULTS: HR maximal, minimum, and median values remained stable. HR CV was similar between T1 and T2, but it decreased significantly at T3 (P < 0.01). Very low values were observed in 4 patients at T3 (HR CV <0.20), and 3 died suddenly within the following 2 months, despite normal NPO.
CONCLUSIONS: Low HR CV is a potential marker of prognosis in ALS.
Susana Pinto; Anabela Pinto; Mamede De Carvalho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  46     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-21     Completed Date:  2012-11-06     Revised Date:  2013-05-01    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Neuromuscular Unit, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal.
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MeSH Terms
Amyotrophic Lateral Sclerosis / complications,  physiopathology*
Death, Sudden*
Diaphragm / physiopathology
Heart Rate / physiology*
Middle Aged
Predictive Value of Tests
Prospective Studies
Respiratory Insufficiency / etiology,  physiopathology*
Retrospective Studies
Comment In:
Muscle Nerve. 2013 Apr;47(4):619-20   [PMID:  23456801 ]
Muscle Nerve. 2013 Apr;47(4):620-1   [PMID:  23456793 ]

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