| Decreased heart rate variability predicts death in amyotrophic lateral sclerosis. | |
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MedLine Citation:
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PMID: 22907223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Some patients with amyotrophic lateral sclerosis (ALS) die suddenly despite normal nocturnal pulse oximetry (NPO), possibly due to dysautonomia. METHODS: Forty-four ALS patients without other medical conditions were studied. Heart rate variability was assessed through finger oximetry. The heart rate coefficient of variation (HR CV) was evaluated during nocturnal sleep. All patients were investigated at study entry (T1); 13 were tested 4 months later (T2), and 21 patients were investigated a further 24 months after entry (T3). Only recordings obtained from patients with normal NPO were accepted. RESULTS: HR maximal, minimum, and median values remained stable. HR CV was similar between T1 and T2, but it decreased significantly at T3 (P < 0.01). Very low values were observed in 4 patients at T3 (HR CV <0.20), and 3 died suddenly within the following 2 months, despite normal NPO. CONCLUSIONS: Low HR CV is a potential marker of prognosis in ALS. |
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Authors:
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Susana Pinto; Anabela Pinto; Mamede De Carvalho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Muscle & nerve Volume: 46 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-21 Completed Date: 2012-11-06 Revised Date: 2013-05-01 |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 341-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Neuromuscular Unit, Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amyotrophic Lateral Sclerosis / complications, physiopathology* Death, Sudden* Diaphragm / physiopathology Female Heart Rate / physiology* Humans Male Middle Aged Oximetry* Predictive Value of Tests Prognosis Prospective Studies Respiratory Insufficiency / etiology, physiopathology* Retrospective Studies |
| Comments/Corrections | |
Comment In:
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Muscle Nerve. 2013 Apr;47(4):619-20
[PMID:
23456801
]
Muscle Nerve. 2013 Apr;47(4):620-1 [PMID: 23456793 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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