Document Detail

Decreased heart rate recovery in patients with heart failure: effect of fluvastatin therapy.
MedLine Citation:
PMID:  16272775     Owner:  NLM     Status:  MEDLINE    
Heart rate recovery is the difference in heart rate at peak exercise and at a specific time interval following the onset of recovery. Attenuated heart rate recovery is an independent predictor of mortality in patients with a history of coronary artery disease. The aim of the present study was to evaluate the effect of a statin on heart rate recovery, particularly in patients with ischemic heart failure and hyperlipidemia. Twenty-nine consecutive hyperlipidemic, stable coronary artery disease patients with heart failure and 19 healthy subjects were enrolled. Heart rate recovery values at the 1st and 3rd minutes and lipid profiles of the patients were evaluated at baseline and following 3 months of treatment with fluvastatin. Compared with healthy subjects, the heart rate recovery values were significantly lower in the heart failure patients in both the 1st and 3rd minutes, respectively (31 +/- 6 versus 19 +/- 7, P < 0.0001; 66 +/- 7 versus 47 +/- 8, P < 0.0001). Heart rate recovery in the 1st and 3rd minutes increased from 19 +/- 7 to 24 +/- 9 and 47 +/- 8 to 57 +/- 11, respectively, following treatment (P < 0.001, P < 0.001). There were no significant correlations among the changes in lipid parameters or HRR in the first and third minutes in the recovery period. The results revealed an improvement in heart rate recovery in heart failure patients by fluvastatin treatment. If this association can be confirmed by other studies, it would be interesting to perform further studies into the mechanism underlying this finding.
Mahmut Tuna Katircibasi; Taner Canatar; Halil Tolga Kocum; Tansel Erol; Goknur Tekin; Senol Demircan; Abdullah Tekin; Alpay Turan Sezgin; Mehmet Baltali; Haldun Muderrisoglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  46     ISSN:  1349-2365     ISO Abbreviation:  -     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-11-07     Completed Date:  2006-03-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  845-54     Citation Subset:  IM    
Department of Cardiology, Baskent University School of Medicine, Ankara, Turkey.
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MeSH Terms
Anticholesteremic Agents / therapeutic use
Coronary Artery Disease / complications,  physiopathology*
Fatty Acids, Monounsaturated / therapeutic use*
Heart Failure / drug therapy*,  physiopathology*
Heart Rate / physiology*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Hyperlipidemias / complications,  physiopathology
Indoles / therapeutic use*
Lipids / blood
Middle Aged
Parasympathetic Nervous System / physiopathology
Recovery of Function
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Fatty Acids, Monounsaturated; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Indoles; 0/Lipids; 93957-54-1/fluvastatin

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