| Decreased heart rate recovery after exercise in patients with congestive heart failure: effect of beta-blocker therapy. | |
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MedLine Citation:
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PMID: 13680550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Decreased heart rate recovery (HRR) is a predictor of mortality in patients with coronary artery disease and preserved left ventricular function. We investigated the changes in HRR and assessed the impact of beta-blockade therapy on these parameters in patients with symptomatic congestive heart failure (CHF). METHODS AND RESULTS: HRR, defined as the difference from peak exercise heart rate (HR) to HR measured at 1, 2, and 3 minutes after maximal exercise test, was studied in 23 stable CHF patients and 12 healthy subjects. Patients with CHF performed a maximal exercise test using a Ramp protocol before and after 6 months of therapy with either metoprolol or carvedilol. Patients with CHF exhibited a significantly attenuated HRR compared with healthy subjects at 1 minute (17.8 +/- 5.8 versus 26.8 +/- 16.2 beats), 2 minutes (34.0 +/- 10.6 versus 48.0 +/- 11.2 bpm) and 3 minutes (41.0 +/- 12.4 versus 60.0 +/-12.4 bpm) after exercise (P<.05 for all parameters). Beta-blocker therapy for 6 months did not significantly improve HRR. CONCLUSION: HRR is markedly attenuated in stable CHF patients compared with healthy subjects. Long-term beta-blocker therapy appears to cause no significant improvement in HRR up to 3 minutes after maximal exercise. |
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Authors:
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Normand Racine; Martine Blanchet; Anique Ducharme; Johanne Marquis; Jean-Marc Boucher; Martin Juneau; Michel White |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cardiac failure Volume: 9 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-09-18 Completed Date: 2004-03-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 296-302 Citation Subset: IM |
Affiliation:
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Department of Medicine, Montreal Heart Institute, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Adult Aged Blood Pressure / drug effects, physiology Carbazoles / therapeutic use Diastole / drug effects, physiology Exercise / physiology* Exercise Test Female Heart Failure / drug therapy, physiopathology* Heart Rate / drug effects, physiology* Humans Male Metoprolol / therapeutic use Middle Aged Oxygen Consumption / drug effects, physiology Predictive Value of Tests Propanolamines / therapeutic use Recovery of Function / drug effects, physiology* Stroke Volume / drug effects, physiology Systole / drug effects, physiology Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 37350-58-6/Metoprolol; 72956-09-3/carvedilol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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