Document Detail

Decreased growth rate of low-birth-weight infants with prolonged maximum renal acid stimulation.
MedLine Citation:
PMID:  8393359     Owner:  NLM     Status:  MEDLINE    
In a prospective randomized study, the urine pH of 170 premature and small-for-gestational-age (SGA) newborns was routinely screened to detect patients with spontaneously developing maximum renal acid stimulation, an obligatory early stage in the development of late metabolic acidosis. Nitrogen assimilation was evaluated from the ratio of urinary nitrogen excretion and intake. Forty-two premature infants and 10 SGA prematures and newborns after intensive care therapy with body weights greater than 1.5 kg and 25 prematures (including 7 SGA infants) with body weights less than 1.5 kg, spontaneously showed urine pH values below 5.4 on two consecutive days, suggesting maximum renal acid stimulation. These patients were randomly given either oral alkali therapy with sodium bicarbonate 2 mmol/kg/day or no therapy for a period of seven days. In both groups, urine pH was controlled daily. Patients in the control group without alkali therapy and with urine pH values less than 5.4 for seven days showed a significant decrease in weight gain and a tendency to decreased nitrogen assimilation. We assume that a regular check of urine pH in low-birth-weight infants is a useful non-invasive method of detecting patients in the early stages of development of late metabolic acidosis, i.e. in the stage of "incipient late metabolic acidosis". This would provide the possibility of starting early effective therapy and thereby reduce the mean duration of admission to neonatal wards.(ABSTRACT TRUNCATED AT 250 WORDS)
H Kalhoff; F Manz; L Diekmann; C Kunz; G J Stock; F Weisser
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  82     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:    1993 Jun-Jul
Date Detail:
Created Date:  1993-08-30     Completed Date:  1993-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  522-7     Citation Subset:  IM    
Pediatric Clinic, Dortmund, Germany.
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MeSH Terms
Acidosis / metabolism,  prevention & control*,  urine
Bicarbonates / therapeutic use
Hydrogen-Ion Concentration
Infant, Low Birth Weight* / growth & development,  urine
Infant, Newborn
Infant, Premature* / growth & development,  urine
Infant, Premature, Diseases / metabolism,  prevention & control*,  urine
Nitrogen / metabolism
Prospective Studies
Sodium / therapeutic use
Sodium Bicarbonate
Urine / chemistry
Weight Gain
Reg. No./Substance:
0/Bicarbonates; 144-55-8/Sodium Bicarbonate; 7440-23-5/Sodium; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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