| Decreased glutathione peroxidase activity in mice in response to nafenopin is caused by changes in selenium metabolism. | |
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MedLine Citation:
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PMID: 8620565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activity of selenium-dependent glutathione peroxidase is known to be reduced in the liver of both rats and mice after exposure to nafenopin, as well as other peroxisome proliferators. The mechanism for this down-regulation is not known, but might involve changes in incorporation of selenium into selenoproteins. In this paper we show that both incorporation of selenium into selenoproteins and the level of selenium in liver is reduced in mice treated with nafenopin. The activity of selenium dependent glutathione peroxidase (GPx), as well as incorporation of selenium into its 23 kD subunit were found to be decreased. Contrary to what might have been expected, the decreased GPx activity was detected concomitantly with a slight increase in mRNA levels after 10 days of treatment, while a small decrease in mRNA levels was detected in treated animals after 26 weeks, together with the decrease in GPx-activity. Incorporation of selenium into liver fatty acid binding protein (L-FABP) was also decreased, even though large increases in protein and mRNA levels were detected. Taken together these data suggest that the decrease in GPx-activity in response to nafenopin is due to post-transcriptional mechanisms, involving changes in selenium metabolism. |
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Authors:
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P Garberg; M Thullberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemico-biological interactions Volume: 99 ISSN: 0009-2797 ISO Abbreviation: Chem. Biol. Interact. Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-06-19 Completed Date: 1996-06-19 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0227276 Medline TA: Chem Biol Interact Country: IRELAND |
Other Details:
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Languages: eng Pagination: 165-77 Citation Subset: IM |
Affiliation:
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National Institute of Occupational Health, Department of Toxicology, Solna, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Northern Body Weight / drug effects Carrier Proteins / metabolism Fatty Acid-Binding Proteins Glutathione Peroxidase / metabolism* Kidney / chemistry, drug effects, metabolism Liver / chemistry, drug effects, metabolism Male Mice Mice, Inbred Strains Microbodies / drug effects, metabolism Myelin P2 Protein / metabolism Nafenopin / pharmacology* Neoplasm Proteins* Nerve Tissue Proteins* Organ Size / drug effects Oxidation-Reduction Proteins / metabolism RNA, Messenger / metabolism Selenium / metabolism* Testis / chemistry, drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Fabp1 protein, mouse; 0/Fabp5 protein, mouse; 0/Fabp7 protein, mouse; 0/Fatty Acid-Binding Proteins; 0/Myelin P2 Protein; 0/Neoplasm Proteins; 0/Nerve Tissue Proteins; 0/Proteins; 0/RNA, Messenger; 3771-19-5/Nafenopin; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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