Document Detail


Decreased glucose uptake in the fetus after maternal exercise.
MedLine Citation:
PMID:  2651847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glucose uptake by muscle is stimulated by exercise. However, during pregnancy, insulin resistance develops in maternal skeletal muscle as a mechanism to spare glucose for use by the developing fetus. The purpose of this study was to determine whether a bout of exercise adversely affects glucose availability to the fetus by increasing glucose uptake in maternal muscle tissue. Pregnant (P) and nonpregnant (NP) rats were divided into rest and exercise groups. Immediately following a 50-min treadmill run, a bolus of glucose (1 g.kg-1) and tracer [1-3H]2-deoxyglucose was injected i.v., and rats underwent a 60-min i.v. glucose tolerance test (IVGTT), after which they were sacrificed. Although glucose levels were lower for P vs NP rats at all time points, prior exercise did not affect glucose levels in either P or NP rats. Plasma insulin levels were augmented in P compared with NP rats and were not significantly altered by prior exercise. Glucose/tracer accumulation was enhanced in red and white gastrocnemius in both P and NP rats, and in soleus of NP rats, by exercise. However, glucose/tracer accumulation in the fetus was decreased by 40% (P less than 0.01) in the exercised dams. These results indicate that uptake of glucose by the fetus is compromised following exercise, as a result of increased glucose uptake by maternal skeletal muscles.
Authors:
J L Treadway; J C Young
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  21     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-01     Completed Date:  1989-06-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM; S    
Affiliation:
Department of Health Sciences, Sargent College of Allied Health Professions, Boston University, MA 02215.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism*
Female
Fetus / metabolism*
Glucose / pharmacokinetics*
Glucose Tolerance Test
Insulin / blood
Lactates / blood
Lactic Acid
Muscles / metabolism*
Physical Exertion*
Pregnancy
Pregnancy, Animal / metabolism*
Prenatal Exposure Delayed Effects
Random Allocation
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Lactates; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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