| Decreased glucose uptake in the fetus after maternal exercise. | |
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MedLine Citation:
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PMID: 2651847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucose uptake by muscle is stimulated by exercise. However, during pregnancy, insulin resistance develops in maternal skeletal muscle as a mechanism to spare glucose for use by the developing fetus. The purpose of this study was to determine whether a bout of exercise adversely affects glucose availability to the fetus by increasing glucose uptake in maternal muscle tissue. Pregnant (P) and nonpregnant (NP) rats were divided into rest and exercise groups. Immediately following a 50-min treadmill run, a bolus of glucose (1 g.kg-1) and tracer [1-3H]2-deoxyglucose was injected i.v., and rats underwent a 60-min i.v. glucose tolerance test (IVGTT), after which they were sacrificed. Although glucose levels were lower for P vs NP rats at all time points, prior exercise did not affect glucose levels in either P or NP rats. Plasma insulin levels were augmented in P compared with NP rats and were not significantly altered by prior exercise. Glucose/tracer accumulation was enhanced in red and white gastrocnemius in both P and NP rats, and in soleus of NP rats, by exercise. However, glucose/tracer accumulation in the fetus was decreased by 40% (P less than 0.01) in the exercised dams. These results indicate that uptake of glucose by the fetus is compromised following exercise, as a result of increased glucose uptake by maternal skeletal muscles. |
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Authors:
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J L Treadway; J C Young |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 21 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-06-01 Completed Date: 1989-06-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 140-5 Citation Subset: IM; S |
Affiliation:
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Department of Health Sciences, Sargent College of Allied Health Professions, Boston University, MA 02215. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism* Female Fetus / metabolism* Glucose / pharmacokinetics* Glucose Tolerance Test Insulin / blood Lactates / blood Lactic Acid Muscles / metabolism* Physical Exertion* Pregnancy Pregnancy, Animal / metabolism* Prenatal Exposure Delayed Effects Random Allocation Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Lactates; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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