Document Detail

Decreased glucose oxidation in preterm infants fed a formula containing medium-chain triglycerides.
MedLine Citation:
PMID:  8433883     Owner:  NLM     Status:  MEDLINE    
Several formulas for preterm infants contain medium-chain triglycerides (MCT) to enhance fat absorption. Although fat absorption with MCT was slightly higher in several studies in preterm infants, a beneficial effect on growth has only been reported in one publication. We hypothesized that when part of the fat blend of preterm formula is substituted by MCT oil, this might lead to a different metabolic pattern in which, due to the preferential oxidation of MCT, an increase in lipogenesis from glucose could lead to an increase in metabolic rate. To study the impact of MCT on glucose metabolism, 18 preterm infants were randomized to receive either an MCT or an LCT formula containing 38- and 6%-by-weight medium-chain fatty acids, respectively, in their fat blend. At 4 wk of age, the metabolic rate, substrate utilization, glucose kinetics, and oxidation were measured by indirect respiratory calorimetry in combination with a constant-rate oral infusion of [U-13C]glucose. The "true" rate of appearance of glucose (Ra "true") was measured from the dilution of the uniformly labeled (m + 6) species of infused tracer, whereas "apparent" rate of appearance of glucose (Ra "apparent") was measured from the dilution of infused tracer C (carbon). The latter was measured by an on-line combustion method using a gas chromatograph-isotope ratio mass spectrometer. At a carbohydrate intake of 8.4, total utilization of carbohydrate was equal in both groups at 7.6 TRUNCATED AT 250 WORDS)
E J Sulkers; H N Lafeber; J B van Goudoever; S C Kalhan; B Beaufrère; P J Sauer
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  33     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-17     Completed Date:  1993-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-5     Citation Subset:  IM    
Erasmus University and Academic Hospital/Sophia Children's Hospital, Rotterdam, The Netherlands.
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MeSH Terms
Dietary Carbohydrates / metabolism
Dietary Fats, Unsaturated / administration & dosage
Energy Metabolism
Glucose / metabolism*
Infant Food*
Infant, Newborn
Infant, Premature / metabolism*
Triglycerides / administration & dosage*
Grant Support
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats, Unsaturated; 0/Triglycerides; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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