Document Detail

Decreased frontal white-matter volume in chronic substance abuse.
MedLine Citation:
PMID:  16004619     Owner:  NLM     Status:  MEDLINE    
There is quite a body of work assessing functional brain changes in chronic substance abuse, much less is known about structural brain abnormalities in this patient population. In this study we used magnetic resonance imaging (MRI) to determine if structural brain differences exist in patients abusing illicit drugs compared to healthy controls. Sixteen substance abusers who abused heroin, cocaine and cannabis but not alcohol and 16 age-, sex- and race-matched controls were imaged on a MRI scanner. Contiguous, 5-mm-thick axial slices were acquired with simultaneous T2 and proton density sequences. Volumes were estimated for total grey and white matter, frontal grey and white matter, ventricles, and CSF using two different methods: a conventional segmentation and a stereological method based on the Cavalieri principle. Overall brain volume differences were corrected for by expressing the volumes of interest as a percentage of total brain volume. Volume measures obtained with the two methods were highly correlated (r=0.65, p<0.001). Substance abusers had significantly less frontal white-matter volume percentage than controls. There were no significant differences in any of the other brain volumes measured. This difference in frontal lobe white matter might be explained by a direct neurotoxic effect of drug use on white matter, a pre-existing abnormality in the development of the frontal lobe or a combination of both effects. This last explanation might be compelling based on the fact that newer concepts on shared aspects of some neuropsychiatric disorders focus on the promotion and inhibition of the process of myelination throughout brain development and subsequent degeneration.
Thomas E Schlaepfer; Eric Lancaster; Rebecca Heidbreder; Eric C Strain; Markus Kosel; Hans-Ulrich Fisch; Godfrey D Pearlson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2005-07-08
Journal Detail:
Title:  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)     Volume:  9     ISSN:  1461-1457     ISO Abbreviation:  Int. J. Neuropsychopharmacol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-02-16     Completed Date:  2006-05-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815893     Medline TA:  Int J Neuropsychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  IM    
Department of Psychiatry, University Hospital, Bonn, Germany.
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MeSH Terms
Brain Mapping
Case-Control Studies
Frontal Lobe / pathology*
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging / methods
Middle Aged
Stereotaxic Techniques
Substance-Related Disorders / pathology*
Grant Support

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