Document Detail

Decreased frequency of exercise-induced ventricular ectopic activity in the second of two consecutive treadmill tests.
MedLine Citation:
PMID:  870247     Owner:  NLM     Status:  MEDLINE    
Two exercise tests were performed with an intervening rest period of 45 minutes in a group of 13 subjects with previously identified exercise-induced ventricular arrhythmias and no resting arrhythmias. Both normal subjects and patients with heart disease were included in the group. The level of stresss was equal in both tests as judged by similar rate-pressure products at peak exercise. There was a significant decrease (P less than 0.05) in the number of VPCs induced by exercise during and after the second test. When the number of VPCs on test I and test II in the same patients were compared, a regression line fitted the data well (r = 0.92). Analysis of the recovery periods revealed significant (P less than 0.01) decreases in systolic blood pressure at one and three minutes post exercise, comparing the second to the first test. The underlying mechanism may be decreased myocardial oxygen demand during the second test as the lowered rate-pressure products during recovery (P less than 0.01) reflect. The results of this study indicate that tests of effectiveness of an antiarrhythmic drug should not be based solely on a decrease in the amount of severity of ventricular irritability between two successive exercise tests, one immediately before and the other following administration of the drug.
D S Sheps; J C Ernst; F R Briese; L V Lopez; C A Conde; A Castellanos; R J Myerburg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  55     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  892-5     Citation Subset:  AIM; IM    
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MeSH Terms
Arrhythmias, Cardiac / etiology,  physiopathology*
Blood Pressure
Exercise Test
Heart Rate
Heart Ventricles / physiopathology*
Middle Aged
Physical Exertion*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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