Document Detail


Decreased frequencies of ABCA1 polymorphisms R219K and V771M in Hungarian patients with cerebrovascular and cardiovascular diseases.
MedLine Citation:
PMID:  16446539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Genetic polymorphisms in ABC transporter A1 (ABCA1) may alter the regulation of plasma high-density lipoprotein (HDL), promoting or protecting from vascular diseases. METHODS: We investigated 244 unrelated, consecutively enrolled patients with ischemic stroke, 150 patients with coronary heart disease (CHD) and 193 blood donors for allele frequencies (AFs) of three common ABCA1 polymorphisms (R219K, V771M and I883M). RESULTS: Compared to controls (30.8 +/- 4.7 and 4.9 +/- 2.2%, respectively), decreased AFs were found in both patient groups for R219K and V771M (28.7 +/- 4.1 and 3.1 +/- 1.6% in stroke, and 25.7 +/- 5.0%; 1.3 +/- 1.3% in CHD patients, respectively). In a subset of stroke patients younger than 50, both variants occurred in significantly lower frequencies (22.4 +/- 5.5 and 1.8 +/- 1.7%, respectively). Similarly, among CHD patients younger than 60, AFs of R219K and V771M (22.6 +/- 7.5 and 0 +/- 1.6%, respectively) were decreased. V771M was almost exclusively (35/36) found in individuals carrying the R219K allele. CONCLUSIONS: Our data confirm earlier observations that ABCA1 R219K and V771M polymorphisms may be associated with a protective role against CHD and extend those to another important pathologic condition, namely stroke.
Authors:
Hajnalka Andrikovics; Endre Pongrácz; Ethkos Kalina; Anikó Szilvási; Charalampos Aslanidis; Gerd Schmitz; Attila Tordai
Related Documents :
20730719 - High concentrations of b-type natriuretic peptide and left ventricular diastolic dysfun...
13678939 - Morphology of atrial myocardium in human pulmonary veins: a postmortem analysis in pati...
16253649 - Asymptomatic atrial fibrillation.
8466099 - Allergic bronchopulmonary aspergillosis in patients with and without evidence of bronch...
11198369 - Cryptosporidiosis in benha, study of some recent modalities in diagnosis and treatment.
19930859 - Amniotic fluid embolism: a comparison between patients who survived and those who died.
22773149 - Comparison of the diagnostic performances of two protocols of hand perfusion scintigrap...
9371109 - Aneurysmal bone cysts of the maxilla: a clinicopathologic review.
22198859 - Thrombosis and occlusion of vascular access in hemodialyzed patients.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-27
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  21     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-14     Completed Date:  2006-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  254-9     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics, National Medical Center, Budapest, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
ATP-Binding Cassette Transporters / genetics*
Adolescent
Adult
Aged
Aged, 80 and over
Angina Pectoris / genetics*
Female
Gene Frequency
Genotype
Humans
Hungary
Male
Middle Aged
Myocardial Infarction / genetics*
Polymorphism, Genetic
Stroke / genetics*
Chemical
Reg. No./Substance:
0/ATP binding cassette transporter 1; 0/ATP-Binding Cassette Transporters

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Spasticity and its association with functioning and health-related quality of life 18 months after s...
Next Document:  Effect of smoking status on outcome after acute ischemic stroke.