Document Detail


Decreased fragile X mental retardation protein (FMRP) is associated with lower IQ and earlier illness onset in patients with schizophrenia.
MedLine Citation:
PMID:  23333116     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The purpose of this study was to investigate Fragile X Syndrome (FXS)-related mechanisms in schizophrenia, including CGG triplet expansion, FMR1 mRNA, and fragile X mental retardation protein (FMRP) levels in lymphocytes. We investigated 36 patients with schizophrenia and 30 healthy controls using Southern blot analysis, mRNA assay, and enzyme-linked immunosorbent assay (ELISA). General intellectual functions were assessed with the Wechsler Adult Intelligence Scale-III, and the clinical symptoms were evaluated with the Positive and Negative Syndrome Scale. Results revealed that, relative to healthy controls, CGG triplet size and FMR1 mRNA were unaltered in patients with schizophrenia. However, the FMRP level was significantly reduced in patients compared with controls. We found an association between lower FMRP levels, reduced IQ, and earlier illness onset in schizophrenia. Chlorpromazine-equivalent antipsychotic dose did not correlate with FMRP levels. These results raise the possibility of impaired translation of FMR1 mRNA, altered epigenetic regulation, or increased degradation of FMRP in schizophrenia, which may play a role in dysfunctional neurodevelopmental processes and impaired neuroplasticity.
Authors:
Tamás Kovács; Oguz Kelemen; Szabolcs Kéri
Related Documents :
9385056 - Quantitation of low abundance mrnas in glial cells using different polymerase chain rea...
24450886 - Met dysregulation is a hallmark of aggressive disease in multiple myeloma patients.
10723556 - Optimized rapid amplification of cdna ends (race) for mapping bacterial mrna transcripts.
19111186 - Cell type-specific analysis of mrna synthesis and decay in vivo with uracil phosphoribo...
24705226 - Identification of cathepsin b from large yellow croaker (pseudosciaena crocea) and its ...
23125006 - Expression and significance of vascular endothelial growth factor c from multiple speci...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Psychiatry research     Volume:  -     ISSN:  1872-7123     ISO Abbreviation:  Psychiatry Res     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
National Psychiatry Center, Budapest, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retro...
Next Document:  Standard chemotherapy with or without bevacizumab in advanced ovarian cancer: quality-of-life outcom...