Document Detail


Decreased fibrinolytic capacity and increased von Willebrand factor levels as indicators of endothelial cell dysfunction in patients with lupus anticoagulant.
MedLine Citation:
PMID:  2501064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over a 6-year period, 10 patients with lupus anticoagulant activity were seen. A history of thrombotic disease was found in 6 patients, but only 3 had systemic autoimmune disease. Reduced fibrinolytic activity after venous occlusion was found in 9 subjects, but only 4 had high von Willebrand factor levels. These changes were unrelated to inflammatory activity, which was ruled out by normal serum protein electrophoresis in all but one case. Human brain thromboplastin dilution test was pathological in all subjects with depressed fibrinolytic activity. These two tests may prove to be of value to single out those LA patients with highest risk for development of thromboembolic disease.
Authors:
T K Nilsson; E Löfvenberg
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical rheumatology     Volume:  8     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  58-63     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry, University Hospital, Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies / analysis*
Blood Coagulation Factors / analysis,  immunology*
Endothelium, Vascular / physiopathology*
Female
Fibrinolysis*
Humans
Lupus Coagulation Inhibitor
Lupus Erythematosus, Systemic / blood,  immunology*
Male
Middle Aged
Retrospective Studies
Thrombophlebitis / blood,  etiology
von Willebrand Factor / analysis*
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Blood Coagulation Factors; 0/Lupus Coagulation Inhibitor; 0/von Willebrand Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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