| Decreased femoral arterial flow during simulated microgravity in the rat. | |
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MedLine Citation:
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PMID: 8063676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether the blood supply to the hindlimbs of rats is altered by the tail-suspension model of weightlessness, rats were chronically instrumented for the measurement of femoral artery flow. Ultrasonic transit-time flow probes were implanted into 8-wk-old Wistar-Furth rats under ketamine-xylazine anesthesia, and, after 24 h of recovery, flow was measured in the normal ambulatory posture. Next, rats were suspended and flow was measured immediately and then daily over the next 4-7 days. Rats were subsequently returned to normal posture, and flow was monitored daily for 1-3 days. Mean arterial flow decreased immediately on the rats being suspended and continued to decrease until a new steady state of approximately 60% of control values was attained at 5 days. On the rats returning to normal posture, flow increased to levels observed before suspension. Quantile-quantile plots of blood flow data revealed a decrease in flow during both systole and diastole. The observed decrease in hindlimb blood flow during suspension suggests a possible role in the etiology of muscular atrophy and bone loss in microgravity. |
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Authors:
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R D Roer; R M Dillaman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 76 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-09-22 Completed Date: 1994-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2125-9 Citation Subset: IM; S |
Affiliation:
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Center for Marine Science Research, University of North Carolina at Wilmington 28403. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Female Femoral Artery / physiology* Hindlimb / blood supply Male Rats Rats, Inbred WF Regional Blood Flow / physiology Tail / physiology Weightlessness / adverse effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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