Document Detail

Decreased fMRI activity in the hippocampus of patients with schizophrenia compared to healthy control participants, tested on a wayfinding task in a virtual town.
MedLine Citation:
PMID:  23352276     Owner:  NLM     Status:  In-Data-Review    
Intact episodic memory requires the ability to make associations between the contextual features of an event, referred to as contextual binding. Binding processes combine different contextual elements into a complete memory representation. It has been proposed that binding errors during the encoding process are responsible for the episodic memory impairments reported in schizophrenia. Since the hippocampus is critical for contextual binding and episodic memory, it was hypothesized that patients with schizophrenia would show a deficit in information processing in the hippocampus, measured with functional magnetic resonance imaging (fMRI). In the current experiment, 21 patients with schizophrenia and 22 healthy control participants were scanned while being tested on navigating in a virtual town (i.e. find the grocery store from the school), a task that was shown to be critically dependent on the hippocampus. Between-group comparisons revealed significantly less activation among patients relative to controls in the left middle frontal gyrus, and right and left hippocampi. We propose that the context and the content are not appropriately linked, therefore affecting the formation of a cognitive map representation in the patient group and eliciting a contextual binding deficit.
Andrée-Anne Ledoux; Jennifer Lynne Phillips; Alain Labelle; Andra Smith; Véronique Déborah Bohbot; Patrice Boyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychiatry research     Volume:  211     ISSN:  1872-7123     ISO Abbreviation:  Psychiatry Res     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  47-56     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
University of Ottawa, Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, Ontario, Canada, K1Z 7K4; University of Ottawa, School of Psychology, 136 Jean-Jacques Lussier, Ottawa, Ontario, Canada, K1N 6N5. Electronic address:
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