| Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma. | |
| | |
MedLine Citation:
|
PMID: 19900756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We compared microRNA profiles between choriocarcinoma and non-cancerous trophoblasts, and revealed that miR-199b was underexpressed in choriocarcinoma. By computational prediction and microarray studies, SET (protein phosphatase 2A inhibitor) was shown to be one of the target genes regulated by miR-199b. Ectopic expression of miR-199b inhibited endogenous SET protein levels and the activity of the luciferase reporter containing the 3'-UTR of SET. Further comparisons of formalin-fixed paraffin-embedded human choriocarcinoma, mole, and non-cancer trophoblast tissues confirmed the initial findings of low miR-199b expression and SET upregulation in choriocarcinomas, suggesting that microRNA-dysregulated SET protein may account for the rapid growth seen with choriocarcinomas. |
| | |
Authors:
|
Angel Chao; Chia-Lung Tsai; Pei-Chi Wei; Swei Hsueh; An-Shine Chao; Chin-Jung Wang; Chi-Neu Tsai; Yun-Shien Lee; Tzu-Hao Wang; Chyong-Huey Lai |
Related Documents
:
|
10918576 - Unmasking of phosphorylation-sensitive epitopes on p53 and mdm2 by a simple western-pho... 2836976 - Cytoskeletal proteins as targets for organophosphorus compound and aliphatic hexacarbon... 2476666 - Stable association of activated pp60src with two tyrosine-phosphorylated cellular prote... 20594956 - Trypanosomatid protein phosphatases. 11238986 - P(ii) signal transduction proteins, pivotal players in microbial nitrogen control. 18708056 - Mammalian bip controls posttranslational er translocation of the hepatitis b virus larg... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-08 |
Journal Detail:
|
Title: Cancer letters Volume: 291 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-03-29 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
|
Languages: eng Pagination: 99-107 Citation Subset: IM |
Copyright Information:
|
2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Line, Tumor Cell Proliferation Choriocarcinoma / chemistry, genetics*, pathology Female Histone Chaperones / analysis, genetics, physiology* Humans MicroRNAs / analysis, physiology* Pregnancy Transcription Factors / analysis, genetics, physiology* Trophoblasts / chemistry Uterine Neoplasms / chemistry, genetics*, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Histone Chaperones; 0/MicroRNAs; 0/SET protein, human; 0/Transcription Factors; 0/mirn199 microRNA, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrasound-triggered release of recombinant tissue-type plasminogen activator from echogenic liposom...
Next Document: PML3 interacts with TRF1 and is essential for ALT-associated PML bodies assembly in U2OS cells.