Document Detail


Decreased expression levels of L-selectin on subsets of leucocytes and increased serum L-selectin in severe psoriasis.
MedLine Citation:
PMID:  11122259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
L-selectin is a leucocyte adhesion molecule involved in leucocyte interactions with vascular endothelial cells. Following leucocyte activation L-selectin is endoproteolytically released from the cell surface. To assess whether psoriasis vulgaris results in systemic leucocyte activation, we examined expression levels of L-selectin on subsets of peripheral blood leucocytes from patients with psoriasis (n = 25) and normal control subjects. Serum levels of soluble L-selectin were quantified by ELISA in patients with psoriasis (n = 75), pustulosis palmaris et plantaris, and contact dermatitis, as well as normal control subjects. Psoriasis severity was evaluated by psoriasis area and severity index (PASI). L-selectin expression levels on CD4+ T cells, B cells, monocytes, and neutrophils from patients with severe-type psoriasis (PASI > or = 15) was significantly decreased compared with leucocytes from normal control subjects. Furthermore, L-selectin expression on CD4+ T cells showed good inverse correlation with PASI scores. Monocyte L-selectin expression was restored when the skin lesions of psoriasis were remitted. The frequencies of L-selectin+ CD4+ T cells or L-selectin+ CD8+ T cells from patients with psoriasis were almost normal. Serum L-selectin levels in patients with severe-type psoriasis were significantly higher than those in normal control subjects. These results suggest that subsets of leucocytes may be activated in psoriasis, and that L-selectin expression levels on some leucocyte subsets, especially CD4+ T cells, tend to correlate with disease severity of psoriasis.
Authors:
M Inaoki; S Sato; Y Shimada; S Kawara; D A Steeber; T F Tedder; K Takehara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  122     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-26     Completed Date:  2001-01-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  484-92     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, Japan. inaoki-m@med.kanazawa-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Enzyme-Linked Immunosorbent Assay / methods
Female
Humans
L-Selectin / blood,  metabolism*
Leukocyte Count
Leukocytes / metabolism*
Male
Middle Aged
Psoriasis / blood,  metabolism*,  physiopathology
Chemical
Reg. No./Substance:
126880-86-2/L-Selectin
Comments/Corrections

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