Document Detail

Decreased expression of galectin-3 in basal cell carcinoma of the skin.
MedLine Citation:
PMID:  10375595     Owner:  NLM     Status:  MEDLINE    
Galectins are beta-galactoside-binding lectins that play multiple roles during tumor progression. Previous work conducted in our laboratory has demonstrated decreased galectin-3 expression in carcinomas from colon, breast, ovary and endometrium, compared to the corresponding normal tissues. In this study, we examined the pattern of galectin-3 expression by immunohistochemistry in a group of 10 basal cell carcinomas of the skin. In the surrounding normal skin, galectin-3 immunostaining was found predominantly in the middle epidermis (spine layer) and eccrine sweat glands. Compared to the normal epidermal cells, basal carcinoma cells observed in all 10 samples examined presented with significantly decreased galectin-3 immunostaining. These data further demonstrates that galectin-3 is down-regulated in a variety of human cancers, including basal cell carcinoma.
V Castronovo; F T Liu; F A van den Brule
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of oncology     Volume:  15     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-05     Completed Date:  1999-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  IM    
Metastasis Research Laboratory, University Hospital, University of Liege, B-4000 Liege 1, Belgium.
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MeSH Terms
Antigens, Differentiation / biosynthesis*,  genetics
Carcinoma, Basal Cell / genetics,  metabolism*,  pathology
Extracellular Matrix / metabolism
Galectin 3
Gene Expression Regulation, Neoplastic*
Head and Neck Neoplasms / genetics,  metabolism,  pathology
Immunoenzyme Techniques
Neoplasm Proteins / biosynthesis,  deficiency*,  genetics
Skin Neoplasms / genetics,  metabolism*,  pathology
Tumor Cells, Cultured / metabolism
Reg. No./Substance:
0/Antigens, Differentiation; 0/Galectin 3; 0/Neoplasm Proteins

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