Document Detail


Decreased expression of Ras GTPase activating protein in human trophoblastic tumors.
MedLine Citation:
PMID:  7747802     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The normally developing placenta undergoes extensive but regulated noninvasive cellular proliferation. Various proto-oncogenes and growth factors have been associated with the regulation of trophoblastic placental growth. Activation of some oncogenes and altered expression of growth factors have been demonstrated in trophoblastic tumors (hydatidiform mole and choriocarcinoma). The ras proto-oncogene plays a key role in the signal transduction cascade of activated growth factors, and is known to be activated or overexpressed in multiple tumor types. Ras GTPase activating protein (RasGAP), a major down-regulator of ras activity, is present at high levels in placenta. To assess the role that Ras-GAP plays in the development of trophoblastic tumors, we performed immunohistochemical analyses with anti RasGAP antibodies of normal placentas, hydatidiform moles, invasive moles, and malignant choriocarcinomas. Normal placentas and noninvasive hydatidiform mole displayed intense positive staining confined to trophoblasts, whereas no staining was observed in the trophoblasts of invasive moles or choriocarcinomas. Thus, there was an inverse correlation between expression levels of RasGAP protein and the invasive potential and malignant phenotype in human trophoblastic tumors. The data indicate that RasGAP may play a regulatory role in trophoblast proliferation and that abolishing its activity may be associated with malignant transformation of these cells.
Authors:
M Ståhle-Bäckdhal; M Inoue; J Zedenius; B Sandstedt; L DeMarco; F Flam; C Silfverswärd; J Andrade; E Friedman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of pathology     Volume:  146     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-15     Completed Date:  1995-06-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1073-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Cell Transformation, Neoplastic / metabolism
Female
GTPase-Activating Proteins
Humans
Immunoenzyme Techniques
Immunosorbent Techniques
Neoplasm Proteins / biosynthesis
Pregnancy
Protein Biosynthesis*
Trophoblastic Neoplasms / metabolism*
Uterine Neoplasms / metabolism*
ras GTPase-Activating Proteins
Chemical
Reg. No./Substance:
0/GTPase-Activating Proteins; 0/Neoplasm Proteins; 0/ras GTPase-Activating Proteins
Comments/Corrections

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